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CCL2 active protein :: C-C motif chemokine 2 protein (CCL2) Active Protein

Scan QR to view Datasheet Catalog #    MBS969200
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

C-C motif chemokine 2 protein (CCL2), Active Protein

★Popular Item★
 Also Known As   

Recombinant Human C-C motif chemokine 2 protein (CCL2) (Active)

 Product Synonym Names    HC11; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1
 Product Gene Name   

CCL2 active protein

[Similar Products]
 Product Synonym Gene Name    MCP1; SCYA2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-99aa, Full Length of Mature Protein
 Sequence    QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT
 OMIM    M24545 mRNA
 3D Structure    ModBase 3D Structure for P13500
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 Host    E Coli
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 Purity/Purification    >=96% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 10-100 ng/ml.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of CCL2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CCL2 active protein

   Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
 Product Categories/Family for CCL2 active protein    Biological Active Protein; Immunology; Chemokine
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 SDS-PAGE of CCL2 active protein    CCL2 active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for CCL2. It may not necessarily be applicable to this product.
 NCBI GI #    4506841
 NCBI GeneID    6347
 NCBI Accession #    NP_002973.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002982.3 [Other Products]
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 UniProt Primary Accession #    P13500 [Other Products]
 UniProt Secondary Accession #    Q9UDF3; B2R4V3 [Other Products]
 UniProt Related Accession #    P13500 [Other Products]
 Molecular Weight    8.7 kDa
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 NCBI Official Full Name    C-C motif chemokine 2
 NCBI Official Synonym Full Names    C-C motif chemokine ligand 2
 NCBI Official Symbol    CCL2 [Similar Products]
 NCBI Official Synonym Symbols   
HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 2
 UniProt Protein Name    C-C motif chemokine 2
 UniProt Synonym Protein Names   
HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
 Protein Family    C-C motif chemokine
 UniProt Gene Name    CCL2 [Similar Products]
 UniProt Synonym Gene Names    MCP1; SCYA2; MCAF; MCP-1 [Similar Products]
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 NCBI Summary for CCL2    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
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 UniProt Comments for CCL2    CCL2: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR2 chemokine receptor binding; chemokine activity; protein kinase activity; receptor binding

Biological Process: angiogenesis; astrocyte cell migration; cell adhesion; cell surface receptor linked signal transduction; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; cytoskeleton organization and biogenesis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; humoral immune response; inflammatory response; JAK-STAT cascade; lipopolysaccharide-mediated signaling pathway; macrophage chemotaxis; MAPKKK cascade; monocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil chemotaxis; organ morphogenesis; positive regulation of GTPase activity; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of T cell activation; protein amino acid phosphorylation; protein kinase B signaling cascade; regulation of cell shape; viral genome replication

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To; Mycobacterium Tuberculosis, Susceptibility To; Neural Tube Defects
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 Research Articles on CCL2    1. conclude that MCP-1/CCL2 plays a significant role in the pathogenesis of sepsis, which has potentially important therapeutic implications
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CCL2 active proteinPathways associated with CCL2 active protein
 Reference Product  PubMed Publications
 TNF active protein  >2204 publications with CCL2 and TNF
 CCL5 active protein  >1480 publications with CCL2 and CCL5
 CCR2 active protein  >1363 publications with CCL2 and CCR2
 JUN active protein  >1307 publications with CCL2 and JUN
 CCR5 active protein  >354 publications with CCL2 and CCR5
 CCR1 active protein  >192 publications with CCL2 and CCR1
 CCR3 active protein  >109 publications with CCL2 and CCR3
 FOS active protein  >91 publications with CCL2 and FOS
 IL1B active protein  >85 publications with CCL2 and IL1B
 CCBP2 active protein  >6 publications with CCL2 and CCBP2
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with CCL2 active proteinOrgans/Tissues associated with CCL2 active protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4951 publications with CCL2 and Inflammation
 Cardiovascular Diseases Antibodies  >2035 publications with CCL2 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1120 publications with CCL2 and Atherosclerosis
 Myocardial Ischemia Antibodies  >434 publications with CCL2 and Myocardial Ischemia
 Liver Diseases Antibodies  >417 publications with CCL2 and Liver Diseases
 Hypertension Antibodies  >388 publications with CCL2 and Hypertension
 Hypersensitivity Antibodies  >342 publications with CCL2 and Hypersensitivity
 Glomerulonephritis Antibodies  >306 publications with CCL2 and Glomerulonephritis
 Lung Injury Antibodies  >268 publications with CCL2 and Lung Injury
 Reperfusion Injury Antibodies  >224 publications with CCL2 and Reperfusion Injury
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6201 publications with CCL2 and Blood
 Vascular Antibodies  >2772 publications with CCL2 and Vascular
 Kidney Antibodies  >1277 publications with CCL2 and Kidney
 Lung Antibodies  >1198 publications with CCL2 and Lung
 Muscle Antibodies  >1114 publications with CCL2 and Muscle
 Brain Antibodies  >1063 publications with CCL2 and Brain
 Bone Antibodies  >803 publications with CCL2 and Bone
 Liver Antibodies  >771 publications with CCL2 and Liver
 Heart Antibodies  >729 publications with CCL2 and Heart
 Bone Marrow Antibodies  >526 publications with CCL2 and Bone Marrow
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