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IGF-I active protein

Scan QR to view Datasheet Catalog #    MBS506125
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
1 mg  /  $315 +1 FREE 8GB USB
5 mg  /  $1,215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGF-I, Active Protein

★Popular Item★
 Also Known As   

Recombinant Human IGF-I

 Product Synonym Names    Human IGF-I (IGF-1); Insulin-like Growth Factor I; Somatamedin C; mechano growth factor; IGF-IA
 Product Gene Name   

IGF-I active protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
 OMIM    X00173 mRNA
 3D Structure    ModBase 3D Structure for P05019
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 Host    E Coli
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 Purity/Purification    Purity is typically 97% as determined by reducing and non-reducing SDS-PAGE
 Form/Format    Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing
0.1% Trifluoroacetic Acid (TFA)
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 Species    Human
 Bioactivity Assay    FDC-P1 cell proliferation
 Bioactivity Acceptance Criteria ED50 (ng/mL)    10 ng/mL
 Bioactivity Acceptance Criteria (Units/mg)    1.0 x 10^5 units/mg
 Reconstitution    Sterile water at 0.1 mg/mL
 Acceptance Criteria LAL (EUs/ug)    <=1.00
 Monomer/Dimer    Monomer
 Endotoxin Level (kinetic LAL analysis)    Typically less than 0.05 EUs/mug protein (50% confidence range)
 Biological Activity    The activity is determined by the dose-dependent proliferation of mouse FDC-P1 cells is typically less than 1.0 ng/mL. This corresponds to an expected specific activity of 1 x 106 units/mg.
 Media Components    Luria Broth
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 Preparation and Storage    12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied.
1 month when stored at 4 degree C after reconstituting as directed.
3 months when stored at -20 degree C to -80 degree C after reconstituting as directed.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of IGF-I active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IGF-I active protein

   Insulin-like growth factor I (IGF-I) is a growth factor that is produced by the liver. IGF-1 production is stimulated by growth hormone (GH). IGF-I binds the insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor to stimulate systemic body growth. IGF-I is one of the most potent activators of the AKT signaling pathway, which stimulates cell proliferation and inhibits programmed cell death. Mature human IGF-I is 100% homologous to bovine and porcine IGF-1 proteins.
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 Gel Data of IGF-I active protein    IGF-I active protein Gel Data image
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 Biological Activity of IGF-I active protein    IGF-I active protein Biological Activity image
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NCBI/Uniprot data below describe general gene information for IGF-I. It may not necessarily be applicable to this product.
 NCBI GI #    11024682
 NCBI GeneID    3479
 NCBI Accession #    NP_000609.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000618.4 [Other Products]
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 UniProt Primary Accession #    P05019 [Other Products]
 UniProt Secondary Accession #    P01343; Q14620; B2RWM7; E9PD02 [Other Products]
 UniProt Related Accession #    P05019 [Other Products]
 Molecular Weight    Non-glycosylated protein, containing 70 amino acids, with a molecular weight of 7.7 kDa.
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 NCBI Official Full Name    insulin-like growth factor I isoform 4 preproprotein
 NCBI Official Synonym Full Names    insulin like growth factor 1
 NCBI Official Symbol    IGF1 [Similar Products]
 NCBI Official Synonym Symbols   
MGF; IGFI; IGF-I
[Similar Products]
 NCBI Protein Information    insulin-like growth factor I
 UniProt Protein Name    Insulin-like growth factor I
 UniProt Synonym Protein Names   
Mechano growth factor; MGF; Somatomedin-C
 UniProt Gene Name    IGF1 [Similar Products]
 UniProt Synonym Gene Names    IBP1; IGF-I; MGF [Similar Products]
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 NCBI Summary for IGF-I    The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
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 UniProt Comments for IGF-I    IGF1: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency). IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Belongs to the insulin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: extracellular region; extracellular space; insulin-like growth factor binding protein complex; plasma membrane

Molecular Function: hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; integrin binding; protein binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cell activation; cell motility; cell proliferation; cellular protein metabolic process; DNA replication; glycolate metabolic process; insulin-like growth factor receptor signaling pathway; muscle development; muscle hypertrophy; myoblast differentiation; myoblast proliferation; myotube cell development; negative regulation of apoptosis; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of glycolysis; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; positive regulation of mitosis; positive regulation of osteoblast differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein import into nucleus, translocation; positive regulation of protein secretion; positive regulation of Ras protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat5 protein; protein kinase B signaling cascade; protein stabilization; proteoglycan biosynthetic process; Ras protein signal transduction; regulation of gene expression; regulation of multicellular organism growth; response to heat; satellite cell compartment self-renewal involved in skeletal muscle regeneration; signal transduction; skeletal development

Disease: Insulin-like Growth Factor I Deficiency
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 Research Articles on IGF-I    1. High IGF-1 expression is Associated with Acne Vulgaris.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IGF-I active proteinPathways associated with IGF-I active protein
 Reference Product  PubMed Publications
 IGF1R active protein  >441 publications with IGF-I and IGF1R
 IGFBP3 active protein  >224 publications with IGF-I and IGFBP3
 IGFBP1 active protein  >72 publications with IGF-I and IGFBP1
 IRS1 active protein  >70 publications with IGF-I and IRS1
 IGFBP2 active protein  >60 publications with IGF-I and IGFBP2
 IRS2 active protein  >41 publications with IGF-I and IRS2
 INSR active protein  >40 publications with IGF-I and INSR
 IGFBP5 active protein  >28 publications with IGF-I and IGFBP5
 IGFBP4 active protein  >23 publications with IGF-I and IGFBP4
 IGFBP6 active protein  >8 publications with IGF-I and IGFBP6
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with IGF-I active proteinOrgans/Tissues associated with IGF-I active protein
 Disease Name  Pubmed Publications
 Acromegaly Antibodies  >129 publications with IGF-I and Acromegaly
 Breast Neoplasms Antibodies  >112 publications with IGF-I and Breast Neoplasms
 Inflammation Antibodies  >87 publications with IGF-I and Inflammation
 Female Urogenital Diseases Antibodies  >87 publications with IGF-I and Female Urogenital Diseases
 Liver Diseases Antibodies  >66 publications with IGF-I and Liver Diseases
 Adenoma Antibodies  >59 publications with IGF-I and Adenoma
 Prostatic Neoplasms Antibodies  >51 publications with IGF-I and Prostatic Neoplasms
 Necrosis Antibodies  >45 publications with IGF-I and Necrosis
 Pituitary Neoplasms Antibodies  >45 publications with IGF-I and Pituitary Neoplasms
 Hypertension Antibodies  >39 publications with IGF-I and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >609 publications with IGF-I and Blood
 Muscle Antibodies  >286 publications with IGF-I and Muscle
 Liver Antibodies  >256 publications with IGF-I and Liver
 Bone Antibodies  >254 publications with IGF-I and Bone
 Brain Antibodies  >203 publications with IGF-I and Brain
 Vascular Antibodies  >117 publications with IGF-I and Vascular
 Ovary Antibodies  >110 publications with IGF-I and Ovary
 Heart Antibodies  >106 publications with IGF-I and Heart
 Connective Tissue Antibodies  >103 publications with IGF-I and Connective Tissue
 Lung Antibodies  >81 publications with IGF-I and Lung
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