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IFNL1 active protein :: Interferon lambda-1 protein (IFNL1) Active Protein

Scan QR to view Datasheet Catalog #    MBS969399
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon lambda-1 protein (IFNL1), Active Protein

★Popular Item★
 Also Known As   

Recombinant Human Interferon lambda-1 protein (IFNL1) (Active)

 Product Synonym Names    IFN-lambda-1; Interleukin-29; IL-29
 Product Gene Name   

IFNL1 active protein

[Similar Products]
 Product Synonym Gene Name    IL29; ZCYTO21 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-200aa, Full Length of Mature Protein
 OMIM    AY129150 mRNA
 3D Structure    ModBase 3D Structure for Q8IU54
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5 ng/ml, corresponding to a specific activity of > 2.0 105 IU/mg.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of IFNL1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for IFNL1 active protein

   Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
 Product Categories/Family for IFNL1 active protein    Biological Active Protein; Immunology; Tumor Necrosis Factor
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 SDS-PAGE of IFNL1 active protein    IFNL1 active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for IFNL1. It may not necessarily be applicable to this product.
 NCBI GI #    26024325
 NCBI GeneID    282618
 NCBI Accession #    NP_742152.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_172140.1 [Other Products]
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 UniProt Primary Accession #    Q8IU54 [Other Products]
 UniProt Secondary Accession #    Q17R34; A0AV25 [Other Products]
 UniProt Related Accession #    Q8IU54 [Other Products]
 Molecular Weight    19.8 kDa
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 NCBI Official Full Name    interferon lambda-1
 NCBI Official Synonym Full Names    interferon lambda 1
 NCBI Official Symbol    IFNL1 [Similar Products]
 NCBI Official Synonym Symbols   
IL29; IL-29
[Similar Products]
 NCBI Protein Information    interferon lambda-1
 UniProt Protein Name    Interferon lambda-1
 UniProt Synonym Protein Names   
Cytokine Zcyto21; Interleukin-29; IL-29
 Protein Family    Interferon
 UniProt Gene Name    IFNL1 [Similar Products]
 UniProt Synonym Gene Names    IL29; ZCYTO21; IFN-lambda-1; IL-29 [Similar Products]
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 NCBI Summary for IFNL1    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNL1    IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.

Protein type: Cell cycle regulation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular region; extracellular space; interleukin-28 receptor complex

Molecular Function: interleukin-28 receptor binding; receptor binding

Biological Process: defense response to virus; innate immune response; negative regulation of cell proliferation; negative regulation of interleukin-13 production; negative regulation of interleukin-5 production; negative regulation of memory T cell differentiation; negative regulation of T cell differentiation; negative regulation of T-helper 2 type immune response; negative regulation of transcription, DNA-dependent; positive regulation of immune response; positive regulation of interferon-gamma production; positive regulation of JAK-STAT cascade; positive regulation of MHC class I biosynthetic process; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of STAT protein
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 Research Articles on IFNL1    1. IFN-lambda1 may play an important role in anti-respiratory syncytial virus infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with IFNL1 active protein
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Type III Interferon Signaling Pathway antibodies  Type III Interferon Signaling Pathway Diagram
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