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Il36b active protein :: Interleukin-36 beta protein (Il36b) Active Protein

Scan QR to view Datasheet Catalog #    MBS969430
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-36 beta protein (Il36b), Active Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Interleukin-36 beta protein (Il36b) (Active)

 Product Synonym Names    Interleukin-1 family member 8
 Product Gene Name   

Il36b active protein

[Similar Products]
 Product Synonym Gene Name    Fil1e; Il1f8 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    31-183aa, Full Length of Mature Protein
 3D Structure    ModBase 3D Structure for Q9D6Z6
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Mus musculus (Mouse)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of > 1.0 105 IU/mg.
 Storage Buffer    0.2 um filtered PBS, pH 7.4, 5% trehalose,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of Il36b active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Il36b active protein

   Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activates p38 MAPK phosphorylation in BMDCs. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4(+) T cells and splenocytes. {ECO:0000250|UniProtKB:Q9NZH7, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
 Product Categories/Family for Il36b active protein    Biological Active Protein; Immunology; Interleukin
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 SDS-PAGE of Il36b active protein    Il36b active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Il36b. It may not necessarily be applicable to this product.
 NCBI GI #    118601193
 NCBI GeneID    69677
 NCBI Accession #    NP_081439.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_027163.4 [Other Products]
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 UniProt Primary Accession #    Q9D6Z6 [Other Products]
 UniProt Secondary Accession #    Q8R461 [Other Products]
 UniProt Related Accession #    Q9D6Z6 [Other Products]
 Molecular Weight    17.4 kDa
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 NCBI Official Full Name    interleukin-36 beta
 NCBI Official Synonym Full Names    interleukin 1 family, member 8
 NCBI Official Symbol    Il1f8 [Similar Products]
 NCBI Official Synonym Symbols   
Il36b; 2310043N20Rik
[Similar Products]
 NCBI Protein Information    interleukin-36 beta
 UniProt Protein Name    Interleukin-36 beta
 UniProt Synonym Protein Names   
Interleukin-1 family member 8; IL-1F8
 Protein Family    Interleukin
 UniProt Gene Name    Il36b [Similar Products]
 UniProt Synonym Gene Names    Fil1e; Il1f8; IL-1F8 [Similar Products]
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 UniProt Comments for Il36b    IL36B: Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Belongs to the IL-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2 A3|2 16.21 cM

Cellular Component: extracellular space

Molecular Function: cytokine activity; interleukin-1 receptor binding

Biological Process: cytokine and chemokine mediated signaling pathway; positive regulation of cytokine production; positive regulation of interleukin-6 production; positive regulation of T cell differentiation
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 Research Articles on Il36b    1. IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with Il36b active protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with Il36b and Inflammation
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