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Il4 active protein :: Interleukin-4 protein (Il4) Active Protein

Scan QR to view Datasheet Catalog #    MBS969448
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $460 +1 FREE 8GB USB
0.25 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-4 protein (Il4), Active Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Interleukin-4 protein (Il4) (Active)

 Product Synonym Names    IL-4; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor
 Product Gene Name   

Il4 active protein

[Similar Products]
 Product Synonym Gene Name    Il-4 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    21-140aa, Full Length of Mature Protein
 Sequence    MHIHGCDKNH LREIIGILNE VTGEGTPCTE MDVPNVLTAT KNTTESELVC RASKVLRIFY LKHGKTPCLK KNSSVLMELQ RLFRAFRCLD SSISCTMNES KSTSLKDFLE SLKSIMQMDY S
 3D Structure    ModBase 3D Structure for P07750
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Mus musculus (Mouse)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant prolifiration of Murine HT-2 cells is less then 2 ng/ml, corresponding to a Specific Activity of > 5 105 IU/mg.
 Storage Buffer    0.2 um filtered, PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of Il4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Il4 active protein

   Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
 Product Categories/Family for Il4 active protein    Biological Active Protein; Immunology; Interleukin
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 SDS-PAGE of Il4 active protein    Il4 active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Il4. It may not necessarily be applicable to this product.
 NCBI GI #    10946584
 NCBI GeneID    16189
 NCBI Accession #    NP_067258.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021283.2 [Other Products]
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 UniProt Primary Accession #    P07750 [Other Products]
 UniProt Related Accession #    P07750 [Other Products]
 Molecular Weight    13.5 kDa
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 NCBI Official Full Name    interleukin-4
 NCBI Official Synonym Full Names    interleukin 4
 NCBI Official Symbol    Il4 [Similar Products]
 NCBI Official Synonym Symbols   
Il-4; BSF-1
[Similar Products]
 NCBI Protein Information    interleukin-4
 UniProt Protein Name    Interleukin-4
 UniProt Synonym Protein Names   
B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1
 Protein Family    Interleukin
 UniProt Gene Name    Il4 [Similar Products]
 UniProt Synonym Gene Names    Il-4; IL-4; BSF-1 [Similar Products]
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 UniProt Comments for Il4    IL4: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in IL4 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the IL-4/IL-13 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11 B1.3|11 31.97 cM

Cellular Component: external side of plasma membrane; extracellular space

Molecular Function: cytokine activity

Biological Process: B cell activation; B cell costimulation; cholesterol metabolic process; defense response to protozoan; innate immune response in mucosa; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of chronic inflammatory response; negative regulation of macrophage activation; negative regulation of nitric oxide biosynthetic process; negative regulation of osteoclast differentiation; negative regulation of T cell activation; negative regulation of transcription, DNA-dependent; positive regulation of activated T cell proliferation; positive regulation of B cell activation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of defense response to virus by host; positive regulation of immunoglobulin production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of STAT protein; regulation of immune response; regulation of inflammatory response; regulation of proton transport; T-helper 1 cell lineage commitment; T-helper 2 cell differentiation
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 Research Articles on Il4    1. conclude that a state of haploinsufficiency for the Il4 gene locus is specifically relevant for IL-4-dependent IgE responses to allergens with the amount of IL-4 produced in the hemizygous condition falling close to the threshold required for switching to IgE production
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Il4 active proteinPathways associated with Il4 active protein
 Reference Product  PubMed Publications
 Il4ra active protein  >403 publications with Il4 and Il4ra
 Il2 active protein  >402 publications with Il4 and Il2
 Il5 active protein  >234 publications with Il4 and Il5
 Csf2 active protein  >19 publications with Il4 and Csf2
 Il13ra1 active protein  >16 publications with Il4 and Il13ra1
 Jak2 active protein  >12 publications with Il4 and Jak2
 Jak3 active protein  >8 publications with Il4 and Jak3
 Jak1 active protein  >6 publications with Il4 and Jak1
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
Diseases associated with Il4 active proteinOrgans/Tissues associated with Il4 active protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >416 publications with Il4 and Inflammation
 Necrosis Antibodies  >378 publications with Il4 and Necrosis
 Hypersensitivity Antibodies  >374 publications with Il4 and Hypersensitivity
 Hypersensitivity, Immediate Antibodies  >304 publications with Il4 and Hypersensitivity, Immediate
 Asthma Antibodies  >267 publications with Il4 and Asthma
 Lung Diseases Antibodies  >250 publications with Il4 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >227 publications with Il4 and Respiratory Hypersensitivity
 Autoimmune Diseases Antibodies  >190 publications with Il4 and Autoimmune Diseases
 Liver Diseases Antibodies  >67 publications with Il4 and Liver Diseases
 Dermatitis, Atopic Antibodies  >59 publications with Il4 and Dermatitis, Atopic
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >107 publications with Il4 and Spleen
 Thymus Antibodies  >40 publications with Il4 and Thymus
 Embryonic Tissue Antibodies  >18 publications with Il4 and Embryonic Tissue
 Mammary Gland Antibodies  >3 publications with Il4 and Mammary Gland
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