NP_001012333.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
13.4 kDa
NCBI Official Full Name
midkine isoform a
NCBI Official Synonym Full Names
midkine
NCBI Protein Information
midkine
UniProt Protein Name
Midkine
UniProt Synonym Protein Names
Amphiregulin-associated protein; ARAP; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein
UniProt Synonym Gene Names
NCBI Summary for MDK
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Comments for MDK
MDK: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Belongs to the pleiotrophin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: extracellular region
Molecular Function: heparin binding
Biological Process: adrenal gland development; Notch signaling pathway; response to wounding
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Products associated with MDK active protein
Pathways associated with MDK active protein
Diseases associated with MDK active protein
Organs/Tissues associated with MDK active protein
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