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NTF4 active protein :: Neurotrophin-4 protein (NTF4) Active Protein

Scan QR to view Datasheet Catalog #    MBS969401 NTF4 active protein
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neurotrophin-4 protein (NTF4), Active Protein

★Popular Item★
 Also Known As   

Recombinant Human Neurotrophin-4 protein (NTF4) (Active)

 Product Synonym Names    NT-4; NT-5; Neutrophic factor 4
 Product Gene Name   

NTF4 active protein

[Similar Products]
 Product Synonym Gene Name    NTF5 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    81-210aa, Full Length of Mature Protein
 Sequence    MGVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A
 OMIM    M86528 Genomic DNA
 3D Structure    ModBase 3D Structure for P34130
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg
 Storage Buffer    0.2 um filtered PBS, pH 5.5,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of NTF4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NTF4 active protein

   Target-derived survival factor for peripheral sensory sympathetic neurons.
 Product Categories/Family for NTF4 active protein    Biological Active Protein; Neuroscience ; Growth Factor
NCBI/Uniprot data below describe general gene information for NTF4. It may not necessarily be applicable to this product.
 NCBI GI #    5453808
 NCBI GeneID    4909
 NCBI Accession #    NP_006170.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006179.4 [Other Products]
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 UniProt Primary Accession #    P34130 [Other Products]
 UniProt Secondary Accession #    Q6FH56 [Other Products]
 UniProt Related Accession #    P34130; AAB20549 [Other Products]
 Molecular Weight    28.1 kDa
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 NCBI Official Full Name    neurotrophin-4 preproprotein
 NCBI Official Synonym Full Names    neurotrophin 4
 NCBI Official Symbol    NTF4 [Similar Products]
 NCBI Official Synonym Symbols   
NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5
[Similar Products]
 NCBI Protein Information    neurotrophin-4
 UniProt Protein Name    Neurotrophin-4
 UniProt Synonym Protein Names   
Neurotrophin-5; NT-5; Neutrophic factor 4
 Protein Family    Neurotrophin
 UniProt Gene Name    NTF4 [Similar Products]
 UniProt Synonym Gene Names    NTF5; NT-4; NT-5 [Similar Products]
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 NCBI Summary for NTF4    This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NTF4    NT-4/5: Target-derived survival factor for peripheral sensory sympathetic neurons. Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O). A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Belongs to the NGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytoplasmic vesicle; endoplasmic reticulum lumen; extracellular region

Molecular Function: growth factor activity; neurotrophin p75 receptor binding; protein binding

Biological Process: adult locomotory behavior; cell-cell signaling; epidermis development; ganglion mother cell fate determination; long-term memory; negative regulation of neuron apoptosis; neurite morphogenesis; regulation of neuron differentiation; sensory organ boundary specification; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Glaucoma 1, Open Angle, O
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 Research Articles on NTF4    1. Meta-analysis found the levels of both NT-3 and NT-4/5 were significantly increased in bipolar disorder patients. Through subgroup analysis, this increase persisted only in patients in depressed state, but not in manic or euthymic state. In addition, we found the differences in NT-3 and NT-4/5 were significantly associated with the duration of illness, but not by the mean age or female proportion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NTF4 active proteinPathways associated with NTF4 active protein
 Reference Product  PubMed Publications
 BDNF active protein  >14 publications with NTF4 and BDNF
 GDNF active protein  >4 publications with NTF4 and GDNF
 NTRK1 active protein  >4 publications with NTF4 and NTRK1
 CNTF active protein  >3 publications with NTF4 and CNTF
 NGFR active protein  >3 publications with NTF4 and NGFR
 NTRK2 active protein  >3 publications with NTF4 and NTRK2
 NTRK3 active protein  >2 publications with NTF4 and NTRK3
 FSHR active protein  >1 publications with NTF4 and FSHR
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 P75(NTR)-mediated Signaling Pathway antibodies  P75(NTR)-mediated Signaling Pathway Diagram
Diseases associated with NTF4 active proteinOrgans/Tissues associated with NTF4 active protein
 Disease Name  Pubmed Publications
 Nerve Degeneration Antibodies  >2 publications with NTF4 and Nerve Degeneration
 Nervous System Diseases Antibodies  >1 publications with NTF4 and Nervous System Diseases
 Memory Disorders Antibodies  >1 publications with NTF4 and Memory Disorders
 Neoplasm Metastasis Antibodies  >1 publications with NTF4 and Neoplasm Metastasis
 Learning Disorders Antibodies  >1 publications with NTF4 and Learning Disorders
 Hyperglycemia Antibodies  >1 publications with NTF4 and Hyperglycemia
 Lung Diseases Antibodies  >1 publications with NTF4 and Lung Diseases
 Breast Neoplasms Antibodies  >1 publications with NTF4 and Breast Neoplasms
 Immune System Diseases Antibodies  >1 publications with NTF4 and Immune System Diseases
 Nervous System Malformations Antibodies  >1 publications with NTF4 and Nervous System Malformations
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >2 publications with NTF4 and Ovary
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