Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Active Protein rightarrow PTH  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ABI1 Antibody
 • Phosphorylated Acetyl-CoA Catboxylase (PACCASE) ELISA Kit
 • TFF3 ELISA Kit
 • keratin 1 (KRT1) ELISA Kit
 • SSTR1 ELISA Kit
 • (Rhesus macaque) Agouti-signaling protein (ASIP) Recombinant Protein
 • TCR, Cbeta1 Antibody
 • leucine rich repeat and fibronectin type III domain containi... ELISA Kit
 • KAPPA LIGHT CHAIN Antibody
 • GNAS Antibody
 • Syndecan 4 (SDC4) ELISA Kit
 • CD45RO Antibody
 • a-Methyl-D,L-serine Biochemical
 • regenerating islet-derived 3 alpha (REG3A) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PTH active protein :: Parathyroid hormone protein (PTH) Active Protein

Scan QR to view Datasheet Catalog #    MBS969121
SDS-PAGE
Unit / Price
0.02 mg  /  $115 +1 FREE 8GB USB
0.1 mg  /  $205 +1 FREE 8GB USB
0.25 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid hormone protein (PTH), Active Protein

★Popular Item★
 Also Known As   

Recombinant Human Parathyroid hormone protein (PTH) (Active)

 Product Synonym Names    PTH; Parathyrin
 Product Gene Name   

PTH active protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    38-65aa, Partial
 Sequence    LMHNLGKHLN SMERVEWLRK KLQDVHNF
 OMIM    V00597 mRNA
 3D Structure    ModBase 3D Structure for P01270
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
Section Bar
 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The specific activity is determined by UMR106 cell/cAMP method, corresponding to a specific activity of > 1.0 104 IU/mg.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
Section Bar
 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of PTH active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PTH active protein

   PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. {ECO:0000269|PubMed:21076856}.
 Product Categories/Family for PTH active protein    Biological Active Protein; Signal Transduction; Hormone
Section Bar
 SDS-PAGE of PTH active protein    PTH active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
 NCBI GI #    4506267
 NCBI GeneID    5741
 NCBI Accession #    NP_000306.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000315.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P01270 [Other Products]
 UniProt Secondary Accession #    Q4VB48; Q9UD38 [Other Products]
 UniProt Related Accession #    P01270 [Other Products]
 Molecular Weight    3.4 kDa
Table BarTOPTable Bar
 NCBI Official Full Name    parathyroid hormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    parathyroid hormone
 NCBI Official Symbol    PTH [Similar Products]
 NCBI Official Synonym Symbols   
PTH1
[Similar Products]
 NCBI Protein Information    parathyroid hormone
 UniProt Protein Name    Parathyroid hormone
 UniProt Synonym Protein Names   
Parathormone; Parathyrin
 Protein Family    Parathyroid hormone
 UniProt Gene Name    PTH [Similar Products]
 UniProt Synonym Gene Names    PTH [Similar Products]
Section Bar
 NCBI Summary for PTH    This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Section Bar
 UniProt Comments for PTH    PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Apoptosis; Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.3

Cellular Component: extracellular region; extracellular space

Molecular Function: hormone activity; peptide hormone receptor binding; protein N-terminus binding; receptor agonist activity; RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding

Biological Process: bone resorption; cAMP metabolic process; cell-cell signaling; G-protein coupled receptor protein signaling pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; phospholipase C activation; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; skeletal development

Disease: Hypoparathyroidism, Familial Isolated
Table BarTOPTable Bar
 Research Articles on PTH    1. Elevated PTH induces the transition of endothelial cells to chondrogenic cells via endothelial-mesenchymal transition, possibly mediated by the nuclear translocation of beta-catenin.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PTH active proteinPathways associated with PTH active protein
 Reference Product  PubMed Publications
 PTHLH active protein  >449 publications with PTH and PTHLH
 FGF23 active protein  >311 publications with PTH and FGF23
 CASR active protein  >259 publications with PTH and CASR
 PTH1R active protein  >230 publications with PTH and PTH1R
 AVP active protein  >62 publications with PTH and AVP
 PTH2R active protein  >18 publications with PTH and PTH2R
 CALCA active protein  >7 publications with PTH and CALCA
 BGLAP active protein  >3 publications with PTH and BGLAP
 GCG active protein  >1 publications with PTH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Vitamin D Synthesis Pathway antibodies  Vitamin D Synthesis Pathway Diagram
Diseases associated with PTH active proteinOrgans/Tissues associated with PTH active protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3510 publications with PTH and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >2966 publications with PTH and Hyperparathyroidism, Secondary
 Bone Diseases, Metabolic Antibodies  >2777 publications with PTH and Bone Diseases, Metabolic
 Hypercalcemia Antibodies  >2525 publications with PTH and Hypercalcemia
 Bone Resorption Antibodies  >2319 publications with PTH and Bone Resorption
 Renal Insufficiency Antibodies  >2285 publications with PTH and Renal Insufficiency
 Osteoporosis Antibodies  >2215 publications with PTH and Osteoporosis
 Hypocalcemia Antibodies  >1471 publications with PTH and Hypocalcemia
 Cardiovascular Diseases Antibodies  >995 publications with PTH and Cardiovascular Diseases
 Fractures, Bone Antibodies  >931 publications with PTH and Fractures, Bone
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >16203 publications with PTH and Parathyroid
 Connective Tissue Antibodies  >2469 publications with PTH and Connective Tissue
 Embryonic Tissue Antibodies  >243 publications with PTH and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions