NP_001334085.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 20.4kDa Accurate Molecular Mass: 20kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
kit ligand isoform 2
NCBI Official Synonym Full Names
kit ligand
NCBI Official Synonym Symbols
Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted [Similar Products]
NCBI Protein Information
kit ligand
UniProt Protein Name
Kit ligand
UniProt Synonym Protein Names
Hematopoietic growth factor KL; Mast cell growth factor; MGF
UniProt Synonym Gene Names
UniProt Comments for SCF
SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10 D1|10 51.4 cM
Cellular Component: cell projection; cytoplasm; cytoskeleton; extracellular region; extracellular space; filopodium; integral component of membrane; lamellipodium; membrane; plasma membrane
Molecular Function: cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding
Biological Process: cell adhesion; embryonic hemopoiesis; germ cell development; germ cell programmed cell death; negative regulation of apoptosis; negative regulation of mast cell apoptosis; neural crest cell migration; ovarian follicle development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction
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Products associated with SCF active protein
Pathways associated with SCF active protein
Diseases associated with SCF active protein
Organs/Tissues associated with SCF active protein
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