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TNFRSF12A active protein :: Tumor necrosis factor receptor superfamily member 12A protein (TNFRSF12A) Active Protein

Scan QR to view Datasheet Catalog #    MBS969311
SDS-PAGE
Unit / Price
0.005 mg  /  $115 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor necrosis factor receptor superfamily member 12A protein (TNFRSF12A), Active Protein

★Popular Item★
 Also Known As   

Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein (TNFRSF12A) (Active)

 Product Synonym Names    Fibroblast growth factor-inducible immediate-early response protein 14; Tweak-receptor; TweakR; CD antigen CD266
 Product Gene Name   

TNFRSF12A active protein

[Similar Products]
 Product Synonym Gene Name    FN14 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    28-80aa, Partial
 Sequence    EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
 OMIM    AF191148 mRNA
 3D Structure    ModBase 3D Structure for Q9NP84
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 Host    E Coli
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 Purity/Purification    >=95% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Lyophilized
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of > 3.3 104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
 Protein Note    Protein will be provided with aseptic processing and endotoxin removal.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Active Protein Note    Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
 Other Notes    Small volumes of TNFRSF12A active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TNFRSF12A active protein

   Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.
 Product Categories/Family for TNFRSF12A active protein    Biological Active Protein; Cancer; Tumor Necrosis Factor
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 SDS-PAGE of TNFRSF12A active protein    TNFRSF12A active protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.
 NCBI GI #    7706186
 NCBI GeneID    51330
 NCBI Accession #    NP_057723.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016639.2 [Other Products]
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 UniProt Primary Accession #    Q9NP84 [Other Products]
 UniProt Secondary Accession #    Q9HCS0; D3DUA6 [Other Products]
 UniProt Related Accession #    Q9NP84 [Other Products]
 Molecular Weight    5.6 kDa
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 12A
 NCBI Official Synonym Full Names    TNF receptor superfamily member 12A
 NCBI Official Symbol    TNFRSF12A [Similar Products]
 NCBI Official Synonym Symbols   
FN14; CD266; TWEAKR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 12A
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 12A
 UniProt Synonym Protein Names   
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF12A [Similar Products]
 UniProt Synonym Gene Names    FN14; FGF-inducible 14; TweakR [Similar Products]
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 UniProt Comments for TNFRSF12A    TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; tumor necrosis factor-mediated signaling pathway
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 Research Articles on TNFRSF12A    1. TWEAK upregulated the expression of Fn14.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TNFRSF12A active proteinPathways associated with TNFRSF12A active protein
 Reference Product  PubMed Publications
 TNFSF12 active protein  >5 publications with TNFRSF12A and TNFSF12
 EDN1 active protein  >2 publications with TNFRSF12A and EDN1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNF Receptor Superfamily (TNFSF) Members Mediating Non-canonical NF-kB Pathway antibodies  TNF Receptor Superfamily (TNFSF) Members Mediating Non-canonical NF-kB Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram
Diseases associated with TNFRSF12A active proteinOrgans/Tissues associated with TNFRSF12A active protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >16 publications with TNFRSF12A and Necrosis
 Inflammation Antibodies  >10 publications with TNFRSF12A and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with TNFRSF12A and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >4 publications with TNFRSF12A and Lung Neoplasms
 Lung Diseases Antibodies  >3 publications with TNFRSF12A and Lung Diseases
 Cardiovascular Diseases Antibodies  >3 publications with TNFRSF12A and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with TNFRSF12A and Heart Diseases
 Disease Models, Animal Antibodies  >2 publications with TNFRSF12A and Disease Models, Animal
 Lung Injury Antibodies  >2 publications with TNFRSF12A and Lung Injury
 Fibrosis Antibodies  >1 publications with TNFRSF12A and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >9 publications with TNFRSF12A and Vascular
 Lung Antibodies  >7 publications with TNFRSF12A and Lung
 Muscle Antibodies  >5 publications with TNFRSF12A and Muscle
 Blood Antibodies  >5 publications with TNFRSF12A and Blood
 Heart Antibodies  >3 publications with TNFRSF12A and Heart
 Eye Antibodies  >3 publications with TNFRSF12A and Eye
 Brain Antibodies  >2 publications with TNFRSF12A and Brain
 Kidney Antibodies  >2 publications with TNFRSF12A and Kidney
 Liver Antibodies  >2 publications with TNFRSF12A and Liver
 Bone Antibodies  >2 publications with TNFRSF12A and Bone
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