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Leptomycin B Antibiotic

Scan QR to view Datasheet Catalog #    MBS651229 Leptomycin B antibiotic
Unit / Price
0.5 mg  /  $565 +1 FREE 8GB USB
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 Product Name   

Leptomycin B, Antibiotic

★Popular Item★
 Also Known As   

Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin)

 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    Streptomyces sp.
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 Purity/Purification    Highly Purified
>99% by HPLC
 Form/Format    Colorless film
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 CAS Number    87081-35-4
 Molecular Formula    C33H48O6
 Solubility    Soluble in ethanol or methanol. Poor water solubility. Ethanol is recommended. Unstable in DMSO.
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 Preparation and Storage    Stable for 6 months at -20 degree C.
 Other Notes    Small volumes of Leptomycin B antibiotic vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Leptomycin B antibiotic

   Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, I B, MPF, MAP/ERK, MDM2/p53, NF- B/I B7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities.
 Product Categories/Family for Leptomycin B antibiotic    Biochemicals; Biochem-Antibiotics
 Molecular Weight    540.7 [Similar Products]
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 Protein Family    Leptomycin B resistance protein
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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