AAA35514.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
94,195 Da
NCBI Official Full Name
anion exchange protein 1
NCBI Official Synonym Full Names
solute carrier family 4 member 1 (Diego blood group)
NCBI Official Synonym Symbols
DI; FR; SW; WD; WR; AE1; CHC; SAO; WD1; BND3; EPB3; SPH4; CD233; EMPB3; RTA1A [Similar Products]
NCBI Protein Information
band 3 anion transport protein
UniProt Protein Name
Band 3 anion transport protein
UniProt Synonym Protein Names
Anion exchange protein 1; AE 1; Anion exchanger 1; Solute carrier family 4 member 1; CD_antigen: CD233
UniProt Synonym Gene Names
NCBI Summary for AE1
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]
UniProt Comments for AE1
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
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Products associated with AE1 antibody pair kit
Pathways associated with AE1 antibody pair kit
Diseases associated with AE1 antibody pair kit
Disease Name |
Pubmed Publications |
Acidosis, Renal Tubular Antibodies |
>75 publications with AE1 and Acidosis, Renal Tubular |
Anemia Antibodies |
>72 publications with AE1 and Anemia |
Hematologic Diseases Antibodies |
>67 publications with AE1 and Hematologic Diseases |
Anemia, Hemolytic Antibodies |
>65 publications with AE1 and Anemia, Hemolytic |
Kidney Diseases Antibodies |
>59 publications with AE1 and Kidney Diseases |
Elliptocytosis, Hereditary Antibodies |
>27 publications with AE1 and Elliptocytosis, Hereditary |
Spherocytosis, Hereditary Antibodies |
>26 publications with AE1 and Spherocytosis, Hereditary |
Renal Tubular Acidosis, Distal, With Hemolytic Anemia Antibodies |
>19 publications with AE1 and Renal Tubular Acidosis, Distal, With Hemolytic Anemia |
Malaria Antibodies |
>13 publications with AE1 and Malaria |
Brain Diseases Antibodies |
>6 publications with AE1 and Brain Diseases |
Organs/Tissues associated with AE1 antibody pair kit
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