AAH59375.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
104,924 Da
NCBI Official Full Name
Ectonucleotide pyrophosphatase/phosphodiesterase 1
NCBI Official Synonym Full Names
ectonucleotide pyrophosphatase/phosphodiesterase 1
NCBI Official Synonym Symbols
M6S1; NPP1; NPPS; PC-1; PCA1; ARHR2; COLED; PDNP1 [Similar Products]
NCBI Protein Information
ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt Protein Name
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt Synonym Protein Names
Nucleotide diphosphataseCurated
UniProt Synonym Gene Names
NCBI Summary for ENPP1
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]
UniProt Comments for ENPP1
By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity and function.
Research Articles on ENPP1
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Products associated with ENPP1 antibody pair kit
Pathways associated with ENPP1 antibody pair kit
Diseases associated with ENPP1 antibody pair kit
Organs/Tissues associated with ENPP1 antibody pair kit
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