AGQ03778.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,646 Da
NCBI Official Full Name
O-6-methylguanine-DNA methyltransferase, partial
NCBI Official Synonym Full Names
O-6-methylguanine-DNA methyltransferase
NCBI Protein Information
methylated-DNA--protein-cysteine methyltransferase
UniProt Protein Name
Methylated-DNA--protein-cysteine methyltransferase
UniProt Synonym Protein Names
6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase
UniProt Synonym Gene Names
NCBI Summary for MGMT
Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
UniProt Comments for MGMT
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Research Articles on MGMT
Precautions
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Disclaimer
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Products associated with MGMT antibody pair kit
Pathways associated with MGMT antibody pair kit
Diseases associated with MGMT antibody pair kit
Organs/Tissues associated with MGMT antibody pair kit
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