NP_006388.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,395 Da
NCBI Official Full Name
ribonuclease H2 subunit A
NCBI Official Synonym Full Names
ribonuclease H2 subunit A
NCBI Official Synonym Symbols
AGS4; JUNB; RNHL; RNHIA; RNASEHI [Similar Products]
NCBI Protein Information
ribonuclease H2 subunit A
UniProt Protein Name
Ribonuclease H2 subunit A
UniProt Synonym Protein Names
Aicardi-Goutieres syndrome 4 protein; AGS4; RNase H(35); Ribonuclease HI large subunit; RNase HI large subunit; Ribonuclease HI subunit A
UniProt Synonym Gene Names
RNASEHI; RNHIA; RNase H2 subunit A; AGS4; RNase HI large subunit [Similar Products]
NCBI Summary for RNASEH2A
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
UniProt Comments for RNASEH2A
Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Research Articles on RNASEH2A
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