NP_659133.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,830 Da
NCBI Official Full Name
torsin-1A
NCBI Official Synonym Full Names
torsin family 1, member A (torsin A)
NCBI Protein Information
torsin-1A
UniProt Protein Name
Torsin-1A
UniProt Synonym Protein Names
Dystonia 1 protein; Torsin ATPase 1 (EC:3.6.4.-); Torsin family 1 member A
UniProt Synonym Gene Names
UniProt Comments for TOR1A
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
Research Articles on TOR1A
Precautions
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Disclaimer
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Diseases associated with TOR1A antibody pair kit
Organs/Tissues associated with TOR1A antibody pair kit
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