AAH11652.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,949 Da
NCBI Official Full Name
BMI1 polycomb ring finger oncogene
NCBI Official Synonym Full Names
BMI1 proto-oncogene, polycomb ring finger
NCBI Official Synonym Symbols
PCGF4; RNF51; FLVI2/BMI1; flvi-2/bmi-1 [Similar Products]
NCBI Protein Information
polycomb complex protein BMI-1
UniProt Protein Name
Polycomb complex protein BMI-1
UniProt Synonym Protein Names
Polycomb group RING finger protein 4; RING finger protein 51
UniProt Synonym Gene Names
UniProt Entry Name
BMI1_HUMAN
NCBI Summary for BMI1
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]
UniProt Comments for BMI1
BMI1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.
Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Motility/polarity/chemotaxis; Ubiquitin ligase; Oncoprotein
Chromosomal Location of Human Ortholog: 10p11.23
Cellular Component: cytoplasm; nucleoplasm; nucleus; PcG protein complex; ubiquitin ligase complex
Molecular Function: protein binding; zinc ion binding
Biological Process: chromatin modification; hemopoiesis; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; positive regulation of fibroblast proliferation; positive regulation of ubiquitin-protein ligase activity; protein sumoylation; regulation of gene expression; segment specification; transcription, DNA-dependent
Research Articles on BMI1
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Products associated with BMI1 antibody pair
Pathways associated with BMI1 antibody pair
Diseases associated with BMI1 antibody pair
Disease Name |
Pubmed Publications |
Disease Models, Animal Antibodies |
>47 publications with BMI1 and Disease Models, Animal |
Congenital Abnormalities Antibodies |
>8 publications with BMI1 and Congenital Abnormalities |
Retinal Diseases Antibodies |
>8 publications with BMI1 and Retinal Diseases |
Neovascularization, Pathologic Antibodies |
>4 publications with BMI1 and Neovascularization, Pathologic |
Ischemia Antibodies |
>2 publications with BMI1 and Ischemia |
Anoxia Antibodies |
>2 publications with BMI1 and Anoxia |
Lung Injury Antibodies |
>2 publications with BMI1 and Lung Injury |
Infant, Newborn, Diseases Antibodies |
>2 publications with BMI1 and Infant, Newborn, Diseases |
Abnormalities, Drug-Induced Antibodies |
>2 publications with BMI1 and Abnormalities, Drug-Induced |
Cardiomyopathy, Hypertrophic Antibodies |
>1 publications with BMI1 and Cardiomyopathy, Hypertrophic |
Organs/Tissues associated with BMI1 antibody pair
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