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anti-4E-BP1 antibody :: 4E-BP1 Antibody

Scan QR to view Datasheet Catalog #    MBS852002
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4E-BP1, Antibody

 Also Known As   

4E-BP1 (Ab-69) Antibody

 Product Synonym Names    4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P/OKCL.6; PHAS-1; PHAS-I
 Product Gene Name   

anti-4E-BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602223
 3D Structure    ModBase 3D Structure for Q13541
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    4E-BP1 (Ab-69) antibody detects endogenous levels of total 4E-BP1 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human 4E-BP1 around the phosphorylation site of threonine 70 (A-K-T-P-P).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-4E-BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-4E-BP1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-4E-BP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-4E-BP1 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:5000
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 Immunohistochemistry (IHC) of anti-4E-BP1 antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Ab-69) antibody.
anti-4E-BP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-4E-BP1 antibody    Western blot analysis of extracts from COS7 cells, treated with EGF (200ng/ml, 30mins), using 4E-BP1 (Ab-69) antibody.
anti-4E-BP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for 4E-BP1. It may not necessarily be applicable to this product.
 NCBI GI #    4758258
 NCBI GeneID    1978
 NCBI Accession #    NP_004086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004095.3 [Other Products]
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 UniProt Primary Accession #    Q13541 [Other Products]
 UniProt Secondary Accession #    Q6IBN3; B2R502; D3DSW8 [Other Products]
 UniProt Related Accession #    Q13541 [Other Products]
 Molecular Weight    12,580 Da
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 NCBI Official Full Name    eukaryotic translation initiation factor 4E-binding protein 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E binding protein 1
 NCBI Official Symbol    EIF4EBP1 [Similar Products]
 NCBI Official Synonym Symbols   
BP-1; 4EBP1; 4E-BP1; PHAS-I
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Synonym Protein Names   
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
 UniProt Gene Name    EIF4EBP1 [Similar Products]
 UniProt Synonym Gene Names    4E-BP1; eIF4E-binding protein 1; PHAS-I [Similar Products]
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 NCBI Summary for 4E-BP1    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for 4E-BP1    Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
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Product References and Citations for anti-4E-BP1 antibody

   Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422. Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810-8816. Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943-10951. Anne-Claude Gingras, Genes & Dev., Feb 1998; 12: 502.
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 Research Articles on 4E-BP1    1. These results demonstrate a previously unrecognized role of IL24 in inhibition of translation, mediated through both phosphorylation of eIF2alpha and dephosphorylation of 4E-BP1, and provide the first direct evidence for translation control of gene-specific expression by IL24
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-4E-BP1 antibodyPathways associated with anti-4E-BP1 antibody
 Reference Product  PubMed Publications
 EIF4E antibody  >460 publications with 4E-BP1 and EIF4E
 MTOR antibody  >444 publications with 4E-BP1 and MTOR
 AKT1 antibody  >49 publications with 4E-BP1 and AKT1
 MAPK1 antibody  >22 publications with 4E-BP1 and MAPK1
 ATM antibody  >11 publications with 4E-BP1 and ATM
 RPS6KB1 antibody  >3 publications with 4E-BP1 and RPS6KB1
 MAPK14 antibody  >2 publications with 4E-BP1 and MAPK14
 EIF4E2 antibody  >2 publications with 4E-BP1 and EIF4E2
 BUB1 antibody  >1 publications with 4E-BP1 and BUB1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-4E-BP1 antibodyOrgans/Tissues associated with anti-4E-BP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >241 publications with 4E-BP1 and Neoplasms
 Hypertrophy Antibodies  >40 publications with 4E-BP1 and Hypertrophy
 Breast Neoplasms Antibodies  >38 publications with 4E-BP1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >34 publications with 4E-BP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >31 publications with 4E-BP1 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >20 publications with 4E-BP1 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >18 publications with 4E-BP1 and Drug Toxicity
 Kidney Diseases Antibodies  >16 publications with 4E-BP1 and Kidney Diseases
 Necrosis Antibodies  >16 publications with 4E-BP1 and Necrosis
 Leukemia, Myeloid, Acute Antibodies  >16 publications with 4E-BP1 and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >161 publications with 4E-BP1 and Muscle
 Blood Antibodies  >110 publications with 4E-BP1 and Blood
 Liver Antibodies  >46 publications with 4E-BP1 and Liver
 Vascular Antibodies  >44 publications with 4E-BP1 and Vascular
 Heart Antibodies  >40 publications with 4E-BP1 and Heart
 Brain Antibodies  >40 publications with 4E-BP1 and Brain
 Kidney Antibodies  >34 publications with 4E-BP1 and Kidney
 Lung Antibodies  >33 publications with 4E-BP1 and Lung
 Pancreas Antibodies  >21 publications with 4E-BP1 and Pancreas
 Prostate Antibodies  >17 publications with 4E-BP1 and Prostate
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