Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow 4E-BP1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Morphine Antibody
 • laminin, beta 1 (LAMB1) ELISA Kit
 • Heat Shock Protein 22 (HSP-22) (HSPB8) ELISA Kit
 • Matrix Metalloproteinase 2 (MMP-2) ELISA Kit
 • Leptin Receptor (LEPR) ELISA Kit
 • L-lactate dehydrogenase A chain (LDHA) Recombinant Protein
 • CK19 - CYFRA21-1 Antibody
 • BCA-1 (CXCL13) Recombinant Protein
 • EPH receptor B1 (EPHB1) ELISA Kit
 • transmembrane protein with EGF-like and two follistatin-like... ELISA Kit
 • A Disintegrin And Metalloproteinase With Thrombospondin 12 (... ELISA Kit
 • NHDF Uninfected Cell Extract Control Antigen
 • Green Fluorescent Protein, Coral Antibody
 • AGER ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-4E-BP1 antibody :: Rabbit 4E-BP1 Antibody

Scan QR to view Datasheet Catalog #    MBS852002
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4E-BP1, Antibody

 Also Known As   

4E-BP1 (Ab-69) Antibody

 Product Synonym Names    4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P/OKCL.6; PHAS-1; PHAS-I
 Product Gene Name   

anti-4E-BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 3D Structure    ModBase 3D Structure for Q60876
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    4E-BP1 (Ab-69) antibody detects endogenous levels of total 4E-BP1 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
Section Bar
 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human 4E-BP1 around the phosphorylation site of threonine 70 (A-K-T-P-P).
 Pathway    Intermediates
Section Bar
 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-4E-BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-4E-BP1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-4E-BP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-4E-BP1 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:5000
Section Bar
 Testing Data of anti-4E-BP1 antibody    Peptide - +
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Ab-69) antibody (#B0402).
anti-4E-BP1 antibody Testing Data image
Section Bar
 Testing Data #2 of anti-4E-BP1 antibody    Western blot analysis of extracts from COS7 cells, treated with EGF (200ng/ml, 30mins), using 4E-BP1 (Ab-69) antibody (#B0402).
anti-4E-BP1 antibody Testing Data #2 image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for 4E-BP1. It may not necessarily be applicable to this product.
 NCBI GI #    122937368
 NCBI GeneID    13685
 NCBI Accession #    NP_031944.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_007918.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q60876 [Other Products]
 UniProt Secondary Accession #    Q3TDS8; Q9CZ40 [Other Products]
 UniProt Related Accession #    Q60876 [Other Products]
 Molecular Weight    12,325 Da
Table BarTOPTable Bar
 NCBI Official Full Name    eukaryotic translation initiation factor 4E-binding protein 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E binding protein 1
 NCBI Official Symbol    Eif4ebp1 [Similar Products]
 NCBI Official Synonym Symbols   
4e-bp1; PHAS-I; AA959816
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Synonym Protein Names   
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
 UniProt Gene Name    Eif4ebp1 [Similar Products]
 UniProt Synonym Gene Names    4E-BP1; eIF4E-binding protein 1; PHAS-I [Similar Products]
 UniProt Entry Name    4EBP1_MOUSE
Section Bar
 UniProt Comments for 4E-BP1    4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation initiation; Translation

Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleus

Molecular Function: protein binding; translation repressor activity; translation initiation factor binding; eukaryotic initiation factor 4E binding

Biological Process: regulation of translation; negative regulation of translational initiation; TOR signaling pathway; negative regulation of translation; insulin receptor signaling pathway; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; regulation of translational initiation; G1/S transition of mitotic cell cycle
Table BarTOPTable Bar
 

Product References and Citations for anti-4E-BP1 antibody

   Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422.
Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810 - 8816.
Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943 - 10951.
Anne-Claude Gingras, Genes & Dev., Feb 1998; 12: 502.
Section Bar
 Research Articles on 4E-BP1    1. The 4E-BP1 may suppress brown adipocyte differentiation and PGC-1alpha expression in white adipose tissues.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-4E-BP1 antibodyDiseases associated with anti-4E-BP1 antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >46 publications with 4E-BP1 and Breast Neoplasms
 Hypertrophy Antibodies  >43 publications with 4E-BP1 and Hypertrophy
 Cardiovascular Diseases Antibodies  >39 publications with 4E-BP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >37 publications with 4E-BP1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >24 publications with 4E-BP1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >23 publications with 4E-BP1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >22 publications with 4E-BP1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >22 publications with 4E-BP1 and Neoplasms, Experimental
 Necrosis Antibodies  >21 publications with 4E-BP1 and Necrosis
 Kidney Diseases Antibodies  >21 publications with 4E-BP1 and Kidney Diseases
Organs/Tissues associated with anti-4E-BP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >124 publications with 4E-BP1 and Blood
 Liver Antibodies  >52 publications with 4E-BP1 and Liver
 Brain Antibodies  >46 publications with 4E-BP1 and Brain
 Heart Antibodies  >42 publications with 4E-BP1 and Heart
 Kidney Antibodies  >39 publications with 4E-BP1 and Kidney
 Lung Antibodies  >37 publications with 4E-BP1 and Lung
 Pancreas Antibodies  >24 publications with 4E-BP1 and Pancreas
 Skin Antibodies  >18 publications with 4E-BP1 and Skin
 Bone Antibodies  >16 publications with 4E-BP1 and Bone
 Intestine Antibodies  >10 publications with 4E-BP1 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions