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anti-4E-BP1 antibody :: Rabbit 4E-BP1 Antibody

Scan QR to view Datasheet Catalog #    MBS853497
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4E-BP1, Antibody

 Also Known As   

4E-BP1 (Phospho-Ser64) Antibody

 Product Synonym Names    4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P/OKCL.6; PHAS-1; PHAS-I; 4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P/OKCL.6; PHAS-2; PHAS-I
 Product Gene Name   

anti-4E-BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602223
 3D Structure    ModBase 3D Structure for Q13541
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    4E-BP1 (Phospho-Ser64) antibody detects endogenous levels of 4E-BP1 only when phosphorylated at serine 64.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human 4E-BP1 around the phosphorylation site of serine 64 (R-N-SP-P-V).
 All Sites    Human: Ser64; Mouse: Ser63; Rat: Ser63
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-4E-BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-4E-BP1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-4E-BP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-4E-BP1 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:1000
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 Testing Data of anti-4E-BP1 antibody    P-peptide - +
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using 4E-BP1 (Phospho-Ser64) antibody (#A0401).
anti-4E-BP1 antibody Testing Data image
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 Testing Data #2 of anti-4E-BP1 antibody    Western blot analysis of extracts from Jurkat cells, treated with Insulin (0.01U/ml, 15mins), using 4E-BP1 (Phospho-Ser64) antibody (#A0401).
anti-4E-BP1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for 4E-BP1. It may not necessarily be applicable to this product.
 NCBI GI #    4758258
 NCBI GeneID    1978
 NCBI Accession #    NP_004086.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004095.3 [Other Products]
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 UniProt Primary Accession #    Q13541 [Other Products]
 UniProt Secondary Accession #    Q6IBN3; B2R502; D3DSW8 [Other Products]
 UniProt Related Accession #    Q13541 [Other Products]
 Molecular Weight    12,580 Da
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 NCBI Official Full Name    eukaryotic translation initiation factor 4E-binding protein 1
 NCBI Official Synonym Full Names    eukaryotic translation initiation factor 4E binding protein 1
 NCBI Official Symbol    EIF4EBP1 [Similar Products]
 NCBI Official Synonym Symbols   
BP-1; 4EBP1; 4E-BP1; PHAS-I
[Similar Products]
 NCBI Protein Information    eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1
 UniProt Protein Name    Eukaryotic translation initiation factor 4E-binding protein 1
 UniProt Synonym Protein Names   
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
 UniProt Gene Name    EIF4EBP1 [Similar Products]
 UniProt Synonym Gene Names    4E-BP1; eIF4E-binding protein 1; PHAS-I [Similar Products]
 UniProt Entry Name    4EBP1_HUMAN
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 NCBI Summary for 4E-BP1    This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for 4E-BP1    4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: nucleoplasm; protein complex; cytoplasm; cytosol

Molecular Function: protein binding; translation repressor activity; eukaryotic initiation factor 4E binding

Biological Process: negative regulation of translational initiation; cellular protein metabolic process; TOR signaling pathway; response to ethanol; translation; insulin receptor signaling pathway; translational initiation; gene expression; positive regulation of mitotic cell cycle; negative regulation of protein complex assembly; G1/S transition of mitotic cell cycle; lung development
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Product References and Citations for anti-4E-BP1 antibody

   Anne-Claude Gingras, Genes & Dev., Jun 1999; 13: 1422.
Guangming Liu, J. Biol. Chem., Mar 2002; 277: 8810 - 8816.
Ya-Ping Jiang, J. Biol. Chem., Mar 2001; 276: 10943 - 10951.
Anne-Claude Gingras, Genes & Dev., Feb 1998; 12: 502.
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 Research Articles on 4E-BP1    1. The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to 4E-BP1 (Phospho-Ser64) Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS850356  4E-BP1 Antibody  MBS8521002  4E-BP1 Polyclonal Antibody
 MBS8520999  4E-BP1 Polyclonal Antibody  MBS9401044  4E-BP1 (Phospho-Thr70) Antibody
 MBS857115  4E-BP1 (Phospho-Thr45) Antibody  MBS2536859  4E-BP1 Polyclonal Antibody
 MBS395375  phospho 4E-BP1 [pT46]  MBS8511613  Phospho-4E-BP1 (Thr45) Antibody
 MBS9401078  4E-BP1 (Phospho-Thr45) Antibody  MBS8519775  4E-BP1 (phospho Thr37) Polyclonal Antibody
Products associated with anti-4E-BP1 antibodyPathways associated with anti-4E-BP1 antibody
 Reference Product  PubMed Publications
 MTOR antibody  >519 publications with 4E-BP1 and MTOR
 EIF4E antibody  >507 publications with 4E-BP1 and EIF4E
 AKT1 antibody  >57 publications with 4E-BP1 and AKT1
 RPTOR antibody  >29 publications with 4E-BP1 and RPTOR
 RHEB antibody  >23 publications with 4E-BP1 and RHEB
 ATM antibody  >12 publications with 4E-BP1 and ATM
 EIF4G1 antibody  >9 publications with 4E-BP1 and EIF4G1
 MLST8 antibody  >5 publications with 4E-BP1 and MLST8
 RPS6KB1 antibody  >5 publications with 4E-BP1 and RPS6KB1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
Diseases associated with anti-4E-BP1 antibodyOrgans/Tissues associated with anti-4E-BP1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >46 publications with 4E-BP1 and Breast Neoplasms
 Hypertrophy Antibodies  >43 publications with 4E-BP1 and Hypertrophy
 Cardiovascular Diseases Antibodies  >39 publications with 4E-BP1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >37 publications with 4E-BP1 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >24 publications with 4E-BP1 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >23 publications with 4E-BP1 and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >22 publications with 4E-BP1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >22 publications with 4E-BP1 and Neoplasms, Experimental
 Necrosis Antibodies  >21 publications with 4E-BP1 and Necrosis
 Kidney Diseases Antibodies  >21 publications with 4E-BP1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >173 publications with 4E-BP1 and Muscle
 Blood Antibodies  >124 publications with 4E-BP1 and Blood
 Vascular Antibodies  >53 publications with 4E-BP1 and Vascular
 Liver Antibodies  >52 publications with 4E-BP1 and Liver
 Brain Antibodies  >46 publications with 4E-BP1 and Brain
 Heart Antibodies  >42 publications with 4E-BP1 and Heart
 Kidney Antibodies  >39 publications with 4E-BP1 and Kidney
 Lung Antibodies  >37 publications with 4E-BP1 and Lung
 Pancreas Antibodies  >24 publications with 4E-BP1 and Pancreas
 Skin Antibodies  >18 publications with 4E-BP1 and Skin
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