NP_004086.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,580 Da
NCBI Official Full Name
eukaryotic translation initiation factor 4E-binding protein 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4E binding protein 1
NCBI Protein Information
eukaryotic translation initiation factor 4E-binding protein 1
UniProt Protein Name
Eukaryotic translation initiation factor 4E-binding protein 1
UniProt Synonym Protein Names
Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
UniProt Synonym Gene Names
NCBI Summary for 4E-BP1
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
UniProt Comments for 4E-BP1
4E-BP1: binds to eIF4E, preventing its assembly into the EIF4F complex and inhibiting cap-dependent translation. Phosphorylation of 4E-BP1 disrupts this binding, activating cap-dependent translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the PI3 kinase pathway.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 8p11.23
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: eukaryotic initiation factor 4E binding; protein binding; translation repressor activity
Biological Process: G1/S transition of mitotic cell cycle; negative regulation of translational initiation; positive regulation of mitotic cell cycle; TOR signaling pathway
Research Articles on 4E-BP1
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Products associated with anti-4E-BP1 antibody
Pathways associated with anti-4E-BP1 antibody
Diseases associated with anti-4E-BP1 antibody
Organs/Tissues associated with anti-4E-BP1 antibody
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