NP_000854.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,568 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 1B
NCBI Official Synonym Symbols
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 1B
UniProt Protein Name
5-hydroxytryptamine receptor 1B
UniProt Synonym Protein Names
S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
UniProt Synonym Gene Names
NCBI Summary for 5-HT-1B
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]
UniProt Comments for 5-HT-1B
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Research Articles on 5-HT-1B
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Products associated with anti-5-HT-1B antibody
Pathways associated with anti-5-HT-1B antibody
Diseases associated with anti-5-HT-1B antibody
Organs/Tissues associated with anti-5-HT-1B antibody
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