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anti-5-HT-2B antibody :: Rabbit anti-Human 5-HT-2B Antibody

Scan QR to view Datasheet Catalog #    MBS854234
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-HT-2B, Antibody

 Also Known As   

5-HT-2B Antibody

 Product Synonym Names    5-hydroxytryptamine receptor 2B; 5-HT-2B; Serotonin receptor 2B; HTR2B
 Product Gene Name   

anti-5-HT-2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601122
 3D Structure    ModBase 3D Structure for P41595
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    5-HT-2B antibody detects endogenous levels of total 5-HT-2B protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human 5-HT-2B.
 Pathway    Neuroscience
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-5-HT-2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-5-HT-2B antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-5-HT-2B antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-5-HT-2B antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:00~1:500, ELISA: 1:1000
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 Testing Data of anti-5-HT-2B antibody    anti-5-HT-2B antibody Testing Data image
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 Testing Data #2 of anti-5-HT-2B antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using 5-HT-2B antibody.
Western blot analysis of extracts from HeLa cells, using 5-HT-2B antibody.
anti-5-HT-2B antibody Testing Data #2 image
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 Testing Data #3 of anti-5-HT-2B antibody    Peptide - +
Immunofluorescence analysis of HeLa cells, using 5-HT-2B antibody.
anti-5-HT-2B antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for 5-HT-2B. It may not necessarily be applicable to this product.
 NCBI GI #    222080049
 NCBI GeneID    3357
 NCBI Accession #    NP_000858.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000867.4 [Other Products]
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 UniProt Primary Accession #    P41595 [Other Products]
 UniProt Secondary Accession #    Q53TI1; Q62221; Q6P523; B2R9D5 [Other Products]
 UniProt Related Accession #    P41595; AAB31827 [Other Products]
 Molecular Weight    54,298 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 2B
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
 NCBI Official Symbol    HTR2B [Similar Products]
 NCBI Official Synonym Symbols   
5-HT2B; 5-HT(2B)
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT 2B receptor; serotonin receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b
 UniProt Protein Name    5-hydroxytryptamine receptor 2B
 UniProt Synonym Protein Names   
Serotonin receptor 2B
 UniProt Gene Name    HTR2B [Similar Products]
 UniProt Synonym Gene Names    5-HT-2B; 5-HT2B [Similar Products]
 UniProt Entry Name    5HT2B_HUMAN
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 NCBI Summary for 5-HT-2B    This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
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 UniProt Comments for 5-HT-2B    5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: heart morphogenesis; cGMP biosynthetic process; negative regulation of autophagy; phosphoinositide 3-kinase cascade; intestine smooth muscle contraction; behavior; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein kinase C activation; embryonic morphogenesis; neural crest cell differentiation; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; positive regulation of cytokine production; response to drug; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; positive regulation of cell division; release of sequestered calcium ion into cytosol; positive regulation of endothelial cell proliferation; phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion
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Product References and Citations for anti-5-HT-2B antibody

   Schmuck K., FEBS Lett. 342:85-90(1994).
Choi D.S., FEBS Lett. 352:393-399(1994).
Kim S.J., Mol. Cell. Probes 14:47-52(2000).
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 Research Articles on 5-HT-2B    1. results of the present study suggest that the HTR2B polymorphism is not likely to be associated with personality traits, including novelty seeking and impulsivity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-5-HT-2B antibodyPathways associated with anti-5-HT-2B antibody
 Reference Product  PubMed Publications
 HCRT antibody  >1 publications with 5-HT-2B and HCRT
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
Diseases associated with anti-5-HT-2B antibodyOrgans/Tissues associated with anti-5-HT-2B antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with 5-HT-2B and Nervous System Diseases
 Inflammation Antibodies  >6 publications with 5-HT-2B and Inflammation
 Brain Diseases Antibodies  >5 publications with 5-HT-2B and Brain Diseases
 Mental Disorders Antibodies  >5 publications with 5-HT-2B and Mental Disorders
 Serotonin Syndrome Antibodies  >3 publications with 5-HT-2B and Serotonin Syndrome
 Liver Diseases Antibodies  >2 publications with 5-HT-2B and Liver Diseases
 Anxiety Disorders Antibodies  >2 publications with 5-HT-2B and Anxiety Disorders
 Movement Disorders Antibodies  >1 publications with 5-HT-2B and Movement Disorders
 Heart Diseases Antibodies  >1 publications with 5-HT-2B and Heart Diseases
 Heart Failure Antibodies  >1 publications with 5-HT-2B and Heart Failure
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with 5-HT-2B and Blood
 Brain Antibodies  >8 publications with 5-HT-2B and Brain
 Intestine Antibodies  >4 publications with 5-HT-2B and Intestine
 Vascular Antibodies  >4 publications with 5-HT-2B and Vascular
 Prostate Antibodies  >2 publications with 5-HT-2B and Prostate
 Muscle Antibodies  >1 publications with 5-HT-2B and Muscle
 Ovary Antibodies  >1 publications with 5-HT-2B and Ovary
 Skin Antibodies  >1 publications with 5-HT-2B and Skin
 Connective Tissue Antibodies  >1 publications with 5-HT-2B and Connective Tissue
 Bone Antibodies  >1 publications with 5-HT-2B and Bone
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