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anti-53BP1 antibody :: anti-Human 53BP1 Antibody

Scan QR to view Datasheet Catalog #    MBS852894
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

53BP1, Antibody

 Also Known As   

53BP1 (Ab-1778) Antibody

 Product Synonym Names    p53-binding protein 1; P531; TP53B; TP53BP1; TRP53BP1; Tumor suppressor p53-binding protein 1
 Product Gene Name   

anti-53BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605230
 3D Structure    ModBase 3D Structure for Q12888
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 Species Reactivity    Human
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 Specificity    53BP1 antibody detects endogenous levels of total 53BP1 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from Internal of human 53BP1.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-53BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-53BP1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-53BP1 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-53BP1 antibody    IHC: 1:50-1:100
ELISA: 1:1000
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 Immunohistochemistry (IHC) of anti-53BP1 antibody    Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using 53BP1 antibody.
anti-53BP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for 53BP1. It may not necessarily be applicable to this product.
 NCBI GI #    213972634
 NCBI GeneID    7158
 NCBI Accession #    NP_001135451.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001141979.2 [Other Products]
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 UniProt Primary Accession #    Q12888 [Other Products]
 UniProt Secondary Accession #    Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4; F8VY86 [Other Products]
 UniProt Related Accession #    Q12888 [Other Products]
 Molecular Weight    213,989 Da
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 NCBI Official Full Name    TP53-binding protein 1 isoform 2
 NCBI Official Synonym Full Names    tumor protein p53 binding protein 1
 NCBI Official Symbol    TP53BP1 [Similar Products]
 NCBI Official Synonym Symbols   
TP53; p202; 53BP1; TDRD30; p53BP1
[Similar Products]
 NCBI Protein Information    TP53-binding protein 1
 UniProt Protein Name    TP53-binding protein 1
 UniProt Gene Name    TP53BP1 [Similar Products]
 UniProt Synonym Gene Names    p53BP1 [Similar Products]
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 NCBI Summary for 53BP1    This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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 UniProt Comments for 53BP1    Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306). In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23760478, PubMed:28241136, PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (). In contrast, it is not required for classic NHEJ and V(D)J recombination (). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).
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Product References and Citations for anti-53BP1 antibody

   Iwabuchi K., J. Biol. Chem. 273:26061-26068(1998). The German cDNA consortium; Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. Nakajima D., Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on 53BP1    1. PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced breast cancer tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-53BP1 antibodyPathways associated with anti-53BP1 antibody
 Reference Product  PubMed Publications
 ATM antibody  >87 publications with 53BP1 and ATM
 H2AFX antibody  >81 publications with 53BP1 and H2AFX
 BRCA1 antibody  >68 publications with 53BP1 and BRCA1
 MDC1 antibody  >52 publications with 53BP1 and MDC1
 TP53 antibody  >14 publications with 53BP1 and TP53
 BLM antibody  >9 publications with 53BP1 and BLM
 E2F1 antibody  >7 publications with 53BP1 and E2F1
 CRB2 antibody  >6 publications with 53BP1 and CRB2
 DCLRE1C antibody  >3 publications with 53BP1 and DCLRE1C
 IFI16 antibody  >2 publications with 53BP1 and IFI16
 Products by Pathway  Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Homologous Recombination Repair Pathway antibodies  Homologous Recombination Repair Pathway Diagram
 Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway antibodies  Homologous Recombination Repair Of Replication-independent Double-strand Breaks Pathway Diagram
 Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway antibodies  Recruitment Of Repair And Signaling Proteins To Double-strand Breaks Pathway Diagram
Diseases associated with anti-53BP1 antibodyOrgans/Tissues associated with anti-53BP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >93 publications with 53BP1 and Neoplasms
 Breast Neoplasms Antibodies  >30 publications with 53BP1 and Breast Neoplasms
 Immune System Diseases Antibodies  >13 publications with 53BP1 and Immune System Diseases
 Nervous System Diseases Antibodies  >10 publications with 53BP1 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >8 publications with 53BP1 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >8 publications with 53BP1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >7 publications with 53BP1 and Adenocarcinoma
 Gastrointestinal Diseases Antibodies  >7 publications with 53BP1 and Gastrointestinal Diseases
 Neoplasms, Experimental Antibodies  >6 publications with 53BP1 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >6 publications with 53BP1 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with 53BP1 and Blood
 Lung Antibodies  >12 publications with 53BP1 and Lung
 Skin Antibodies  >11 publications with 53BP1 and Skin
 Prostate Antibodies  >7 publications with 53BP1 and Prostate
 Bone Antibodies  >6 publications with 53BP1 and Bone
 Brain Antibodies  >5 publications with 53BP1 and Brain
 Thyroid Antibodies  >2 publications with 53BP1 and Thyroid
 Bone Marrow Antibodies  >2 publications with 53BP1 and Bone Marrow
 Pancreas Antibodies  >2 publications with 53BP1 and Pancreas
 Muscle Antibodies  >2 publications with 53BP1 and Muscle
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