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anti-ABCA1 antibody :: ABCA1 (clone: HJ1) Antibody

Scan QR to view Datasheet Catalog #    MBS555095
Unit / Price
0.1 mL  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCA1 (clone: HJ1), Antibody

 Also Known As   

ABCA1 (clone: HJ1), Monoclonal Antibody, Mouse

 Product Gene Name   

anti-ABCA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    205400
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 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Protein G Purified - Liquid
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 Type Info    Mouse IgG
 Immunogen    50 kDa N-terminal extracellular loop of ABCA1 (AA)
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 Other Notes    Small volumes of anti-ABCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ABCA1 antibody    Antibodies; Neurodegenerative Disease; ABCA1
 Applications Tested/Suitable for anti-ABCA1 antibody   

Western Blot (WB)

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 Testing Data of anti-ABCA1 antibody    anti-ABCA1 antibody Testing Data image
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 Testing Data of anti-ABCA1 antibody    anti-ABCA1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ABCA1. It may not necessarily be applicable to this product.
 NCBI GI #    21536376
 NCBI GeneID    19
 NCBI Accession #    NP_005493.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005502.3 [Other Products]
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 UniProt Secondary Accession #    Q5VX33; Q96S56; Q96T85; Q9NQV4; Q9UN06; Q9UN07; Q9UN08; Q9UN09 [Other Products]
 UniProt Related Accession #    O95477 [Other Products]
 Molecular Weight    254,302 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family A member 1
 NCBI Official Synonym Full Names    ATP binding cassette subfamily A member 1
 NCBI Official Symbol    ABCA1 [Similar Products]
 NCBI Official Synonym Symbols   
TGD; ABC1; CERP; ABC-1; HDLDT1
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 1
 UniProt Protein Name    ATP-binding cassette sub-family A member 1
 UniProt Synonym Protein Names   
ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein
 Protein Family    ABC transporter A family
 UniProt Gene Name    ABCA1 [Similar Products]
 UniProt Synonym Gene Names    ABC1; CERP; ABC-1; ATP-binding cassette 1 [Similar Products]
 UniProt Entry Name    ABCA1_HUMAN
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 NCBI Summary for ABCA1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA1    ABCA1: an ATP-binding cassette (ABC) transporter that regulates cholesterol homeostasis and insulin secretion in beta-cells, and protects against cardiovascular disease. Inactivation of ABCA1 in beta-cells markedly impairs glucose tolerance and insulin secretion in mice. Rosiglitazone, an activator of the peroxisome proliferator-activated receptor-gamma, upregulates ABCA1 in beta-cells. ABCA1 expression in beta-cells is required for the beneficial effects of rosiglitazone on glucose tolerance. Mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins, modulating HDL levels and atherogenesis. Induced by bacterial lipopolysaccharides (LPS) and repressed by ZNF202. Phosphorylation on Ser-2054 regulates phospholipid efflux. Unsaturated fatty acids destabilize ABCA1 by activating a PKC-delta pathway that phosphorylates ABCA1 serines. Defects in ABCA1 are a cause of high density lipoprotein deficiencies.

Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: Golgi apparatus; endocytic vesicle; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; phagocytic vesicle; lipid raft; external side of plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATPase activity; cholesterol binding; apolipoprotein binding; ATPase binding; apolipoprotein A-I binding; small GTPase binding; protein binding; syntaxin binding; phospholipid transporter activity; cholesterol transporter activity; phospholipid binding; anion transmembrane transporter activity; ATP binding; receptor binding

Biological Process: response to drug; cholesterol metabolic process; regulation of Cdc42 protein signal transduction; intracellular cholesterol transport; cholesterol efflux; lipoprotein metabolic process; cellular lipid metabolic process; endosome transport; phospholipid translocation; G-protein coupled receptor protein signaling pathway; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; platelet dense granule organization and biogenesis; lysosome organization and biogenesis; response to low density lipoprotein stimulus; positive regulation of cAMP biosynthetic process; protein amino acid lipidation; interleukin-1 beta secretion; phagocytosis, engulfment; response to nutrient; peptide secretion; phospholipid homeostasis

Disease: Hypoalphalipoproteinemia, Primary; Tangier Disease; Hypercholesterolemia, Familial
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Product References and Citations for anti-ABCA1 antibody

   Wahrle SE, Jiang H, Parsadanian M, Legleiter J, Han X, Fryer JD, Kowalewski T, and Holtzman DM (2004). ABCA1 is Required for Normal Central Nervous System ApoE Levels and for Lipidation of Astrocyte-secreted apoE. J Biol. Chem. 279(39):40987.

Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM and Holtzman DM (2005). Deletion of Abca1 Increases Abeta Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease. J. Biol. Chem. 280(52):43236.
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 Research Articles on ABCA1    1. New evidence is provided of an effect of ABCA1 variants on Alzheimer's disease risk, highlighting the importance of high throughput sequencing in the identification of rare variation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCA1 antibodyPathways associated with anti-ABCA1 antibody
 Reference Product  PubMed Publications
 APOE antibody  >405 publications with ABCA1 and APOE
 NR1H3 antibody  >261 publications with ABCA1 and NR1H3
 APOA1 antibody  >170 publications with ABCA1 and APOA1
 APOB antibody  >97 publications with ABCA1 and APOB
 PLTP antibody  >35 publications with ABCA1 and PLTP
 PPARA antibody  >13 publications with ABCA1 and PPARA
 NR1H2 antibody  >11 publications with ABCA1 and NR1H2
 SPTLC1 antibody  >2 publications with ABCA1 and SPTLC1
 CREBBP antibody  >1 publications with ABCA1 and CREBBP
 ARHGEF11 antibody  >1 publications with ABCA1 and ARHGEF11
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with anti-ABCA1 antibodyOrgans/Tissues associated with anti-ABCA1 antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >881 publications with ABCA1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >665 publications with ABCA1 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >310 publications with ABCA1 and Dyslipidemias
 Inflammation Antibodies  >277 publications with ABCA1 and Inflammation
 Tangier Disease Antibodies  >234 publications with ABCA1 and Tangier Disease
 Liver Diseases Antibodies  >176 publications with ABCA1 and Liver Diseases
 Familial HDL deficiency Antibodies  >169 publications with ABCA1 and Familial HDL deficiency
 Heart Diseases Antibodies  >167 publications with ABCA1 and Heart Diseases
 Hypoalphalipoproteinemias Antibodies  >149 publications with ABCA1 and Hypoalphalipoproteinemias
 Peripheral Nervous System Diseases Antibodies  >140 publications with ABCA1 and Peripheral Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >958 publications with ABCA1 and Liver
 Blood Antibodies  >867 publications with ABCA1 and Blood
 Vascular Antibodies  >337 publications with ABCA1 and Vascular
 Brain Antibodies  >199 publications with ABCA1 and Brain
 Intestine Antibodies  >120 publications with ABCA1 and Intestine
 Muscle Antibodies  >97 publications with ABCA1 and Muscle
 Kidney Antibodies  >95 publications with ABCA1 and Kidney
 Bone Antibodies  >93 publications with ABCA1 and Bone
 Lung Antibodies  >84 publications with ABCA1 and Lung
 Bone Marrow Antibodies  >81 publications with ABCA1 and Bone Marrow
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