NP_000383.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
174,207 Da
NCBI Official Full Name
canalicular multispecific organic anion transporter 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
NCBI Protein Information
canalicular multispecific organic anion transporter 1; canalicular multidrug resistance protein; multidrug resistance-associated protein 2; ATP-binding cassette sub-family C member 2
UniProt Protein Name
Canalicular multispecific organic anion transporter 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
UniProt Synonym Gene Names
UniProt Entry Name
MRP2_HUMAN
NCBI Summary for ABCC2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC2
ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Protein type: Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: intercellular canaliculus; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: protein domain specific binding; protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding
Biological Process: prostaglandin transport; metabolic process; response to heat; response to estrogen stimulus; transport; response to arsenic; multidrug transport; response to methotrexate; response to oxidative stress; cellular chloride ion homeostasis; transmembrane transport
Disease: Dubin-johnson Syndrome
Research Articles on ABCC2
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Products associated with anti-ABCC2 antibody
Pathways associated with anti-ABCC2 antibody
Diseases associated with anti-ABCC2 antibody
Organs/Tissues associated with anti-ABCC2 antibody
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