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anti-ABCC2 antibody :: Rabbit anti-Human ABCC2 Antibody

Scan QR to view Datasheet Catalog #    MBS851530
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCC2, Antibody

 Also Known As   

ABCC2 Antibody

 Product Synonym Names    Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2 ; ABCC2 ; CMOAT; CMOAT1; CMRP; MRP2
 Product Gene Name   

anti-ABCC2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601107
 3D Structure    ModBase 3D Structure for Q92887
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    ABCC2 antibody detects endogenous levels of total ABCC2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human ABCC2.
 Pathway    Cancer/Apoptosis
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-ABCC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ABCC2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ABCC2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ABCC2 antibody    WB: 1:500~1:1000, ELISA: 1:10000
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 Testing Data of anti-ABCC2 antibody    Western blot analysis of extracts from RAW264.7 cells, using ABCC2 antibody.
anti-ABCC2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ABCC2. It may not necessarily be applicable to this product.
 NCBI GI #    4557481
 NCBI GeneID    1244
 NCBI Accession #    NP_000383.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000392.4 [Other Products]
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 UniProt Primary Accession #    Q92887 [Other Products]
 UniProt Secondary Accession #    Q14022; Q5T2B1; Q92500; Q92798; Q99663; Q9UMS2; B2RMT8 [Other Products]
 UniProt Related Accession #    Q92887 [Other Products]
 Molecular Weight    174,207 Da
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 NCBI Official Full Name    canalicular multispecific organic anion transporter 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
 NCBI Official Symbol    ABCC2 [Similar Products]
 NCBI Official Synonym Symbols   
DJS; MRP2; cMRP; ABC30; CMOAT
[Similar Products]
 NCBI Protein Information    canalicular multispecific organic anion transporter 1; canalicular multidrug resistance protein; multidrug resistance-associated protein 2
 UniProt Protein Name    Canalicular multispecific organic anion transporter 1
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC2 [Similar Products]
 UniProt Synonym Gene Names    CMOAT; CMOAT1; CMRP; MRP2 [Similar Products]
 UniProt Entry Name    MRP2_HUMAN
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 NCBI Summary for ABCC2    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCC2    ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Protein type: Transporter, ABC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: intercellular canaliculus; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: prostaglandin transport; transport; metabolic process; response to estrogen stimulus; response to heat; response to arsenic; multidrug transport; response to oxidative stress; response to methotrexate; cellular chloride ion homeostasis; transmembrane transport

Disease: Dubin-johnson Syndrome
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Product References and Citations for anti-ABCC2 antibody

   Taniguchi K., Cancer Res. 56:4124-4129(1996).
Kool M., Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
Buechler M., J. Biol. Chem. 271:15091-15098(1996).
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 Research Articles on ABCC2    1. The ABCC2 G1249A polymorphism is significantly associated with a decreased risk of antiepileptic drug resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCC2 antibodyPathways associated with anti-ABCC2 antibody
 Reference Product  PubMed Publications
 SLCO1B1 antibody  >48 publications with ABCC2 and SLCO1B1
 SLCO1B3 antibody  >32 publications with ABCC2 and SLCO1B3
 NR1H4 antibody  >5 publications with ABCC2 and NR1H4
 SLCO4A1 antibody  >2 publications with ABCC2 and SLCO4A1
 RDX antibody  >1 publications with ABCC2 and RDX
 HNF4A antibody  >1 publications with ABCC2 and HNF4A
 PDZK1 antibody  >1 publications with ABCC2 and PDZK1
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Irinotecan Pathway antibodies  Irinotecan Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
Diseases associated with anti-ABCC2 antibodyOrgans/Tissues associated with anti-ABCC2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >79 publications with ABCC2 and Liver Diseases
 Cholestasis Antibodies  >67 publications with ABCC2 and Cholestasis
 Nervous System Diseases Antibodies  >35 publications with ABCC2 and Nervous System Diseases
 Brain Diseases Antibodies  >31 publications with ABCC2 and Brain Diseases
 Drug-Induced Liver Injury Antibodies  >29 publications with ABCC2 and Drug-Induced Liver Injury
 Liver Neoplasms Antibodies  >24 publications with ABCC2 and Liver Neoplasms
 Kidney Diseases Antibodies  >23 publications with ABCC2 and Kidney Diseases
 Breast Neoplasms Antibodies  >22 publications with ABCC2 and Breast Neoplasms
 Jaundice, Chronic Idiopathic Antibodies  >21 publications with ABCC2 and Jaundice, Chronic Idiopathic
 Colorectal Neoplasms Antibodies  >18 publications with ABCC2 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >380 publications with ABCC2 and Liver
 Kidney Antibodies  >157 publications with ABCC2 and Kidney
 Intestine Antibodies  >98 publications with ABCC2 and Intestine
 Brain Antibodies  >58 publications with ABCC2 and Brain
 Lung Antibodies  >29 publications with ABCC2 and Lung
 Placenta Antibodies  >25 publications with ABCC2 and Placenta
 Bone Antibodies  >9 publications with ABCC2 and Bone
 Testis Antibodies  >5 publications with ABCC2 and Testis
 Ovary Antibodies  >4 publications with ABCC2 and Ovary
 Stomach Antibodies  >3 publications with ABCC2 and Stomach
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