NP_000343.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
5,468 Da
NCBI Official Full Name
ATP-binding cassette sub-family C member 8 isoform 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 8
NCBI Official Synonym Symbols
HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2 [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family C member 8
UniProt Protein Name
ATP-binding cassette sub-family C member 8
UniProt Synonym Protein Names
Sulfonylurea receptor 1
UniProt Synonym Gene Names
NCBI Summary for ABCC8
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
UniProt Comments for ABCC8
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K+ channels and insulin release.
Research Articles on ABCC8
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Products associated with anti-ABCC8 antibody
Pathways associated with anti-ABCC8 antibody
Diseases associated with anti-ABCC8 antibody
Organs/Tissues associated with anti-ABCC8 antibody
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