NP_001086.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,700 Da
NCBI Official Full Name
acid-sensing ion channel 1 isoform b
NCBI Official Synonym Full Names
acid sensing ion channel subunit 1
NCBI Protein Information
acid-sensing ion channel 1
UniProt Protein Name
Acid-sensing ion channel 1
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2
UniProt Synonym Gene Names
NCBI Summary for ACCN2
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
UniProt Comments for ACCN2
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.
Research Articles on ACCN2
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Products associated with anti-ACCN2 antibody
Diseases associated with anti-ACCN2 antibody
Organs/Tissues associated with anti-ACCN2 antibody
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