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anti-ACTHR antibody :: Rabbit anti-Human, mouse ACTHR Antibody

Scan QR to view Datasheet Catalog #    MBS001661 anti-ACTHR antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTHR, Antibody

 Also Known As   

Rabbit ACTHR Antibody

 Product Gene Name   

anti-ACTHR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_000018.9 (13882043..13915535, complement). Location: 18p11.2
 OMIM    202200
 3D Structure    ModBase 3D Structure for Q01718
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ACTHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ACTHR antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ACTHR. It may not necessarily be applicable to this product.
 NCBI GI #    4505127
 NCBI GeneID    4158
 NCBI Accession #    NP_000520.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000529.2 [Other Products]
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 UniProt Primary Accession #    Q01718 [Other Products]
 UniProt Secondary Accession #    Q3MI45; Q504X6; A8K016 [Other Products]
 UniProt Related Accession #    Q01718 [Other Products]
 Molecular Weight    33,927 Da
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 NCBI Official Full Name    adrenocorticotropic hormone receptor
 NCBI Official Synonym Full Names    melanocortin 2 receptor (adrenocorticotropic hormone)
 NCBI Official Symbol    MC2R [Similar Products]
 NCBI Official Synonym Symbols   
ACTHR
[Similar Products]
 NCBI Protein Information    adrenocorticotropic hormone receptor; MC2 receptor; ACTH receptor; corticotropin receptor; adrenocorticotropin receptor
 UniProt Protein Name    Adrenocorticotropic hormone receptor
 UniProt Synonym Protein Names   
Adrenocorticotropin receptor; Melanocortin receptor 2
 UniProt Gene Name    MC2R [Similar Products]
 UniProt Synonym Gene Names    ACTHR; ACTH receptor; ACTH-R; MC2-R [Similar Products]
 UniProt Entry Name    ACTHR_HUMAN
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 NCBI Summary for ACTHR    MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTHR    MC2R: Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase. Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1); also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; melanocortin receptor activity; adrenocorticotropin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; placenta development

Disease: Glucocorticoid Deficiency 1
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 Research Articles on ACTHR    1. Significant differences in the gene expression of aldosterone synthase and adrenocorticotropic hormone receptor distinguishes adrenal neoplasms from primary aldosteronism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTHR antibodyPathways associated with anti-ACTHR antibody
 Reference Product  PubMed Publications
 POMC antibody  >110 publications with ACTHR and POMC
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with anti-ACTHR antibodyOrgans/Tissues associated with anti-ACTHR antibody
 Disease Name  Pubmed Publications
 GLUCOCORTICOID DEFICIENCY 1 Antibodies  >32 publications with ACTHR and GLUCOCORTICOID DEFICIENCY 1
 Neoplasms Antibodies  >16 publications with ACTHR and Neoplasms
 Hyperplasia Antibodies  >7 publications with ACTHR and Hyperplasia
 Inflammation Antibodies  >5 publications with ACTHR and Inflammation
 Carcinoma Antibodies  >5 publications with ACTHR and Carcinoma
 Drug Toxicity Antibodies  >4 publications with ACTHR and Drug Toxicity
 Hypertension Antibodies  >4 publications with ACTHR and Hypertension
 Adenocarcinoma Antibodies  >3 publications with ACTHR and Adenocarcinoma
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with ACTHR and Prenatal Exposure Delayed Effects
 Cardiovascular Diseases Antibodies  >2 publications with ACTHR and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >64 publications with ACTHR and Adrenal Gland
 Brain Antibodies  >36 publications with ACTHR and Brain
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