Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ADAM 17  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PON1 ELISA Kit
 • Cathepsin L1 (CTSL1) Recombinant Protein
 • Anaerobic ribonucleoside-triphosphate reductase (nrdD) Recombinant Protein
 • HSP60 Recombinant Protein
 • Transferrin (TF) Antibody
 • V-Ets Erythroblastosis Virus E26 Oncogene Homolog 1 (ETS1) ELISA Kit
 • eNOS Antibody
 • Follistatin (FS) ELISA Kit
 • PAI-1 ELISA Kit
 • LOXL1 Antibody
 • Xanthine dehydrogenase-oxidase (XDH), partial Recombinant Protein
 • Histamine (HIS) ELISA Kit
 • ATP-binding cassette, sub-family B (MDR-TAP) , member 11 (AB... ELISA Kit
 • MTM1 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ADAM 17 antibody :: ADAM 17 Antibody

Scan QR to view Datasheet Catalog #    MBS858804
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM 17, Antibody

★Popular Item★
 Also Known As   

ADAM 17 (Phospho-Thr735) Antibody

 Product Synonym Names    ADA17; ADAM 17; CD156b antigen; CSVP; EC 3.4.24.86; TACE; TNF-alpha convertase; TNF-alpha-converting enzyme; a disintegrin and metalloproteinase domain 17; snake venom-like protease
 Product Gene Name   

anti-ADAM 17 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603639
 3D Structure    ModBase 3D Structure for P78536
Section Bar
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    ADAM 17 (Phospho-Thr735) antibody detects endogenous levels of ADAM 17 only when phosphorylated at threonine 735.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Section Bar
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human ADAM 17 around the phosphorylation site of threonine 735 (P-Q-TP-P-G).
 All Sites    Human: Thr735
Mouse: Thr735
Rat: Thr735
Section Bar
 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-ADAM 17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-ADAM 17 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ADAM 17 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ADAM 17 antibody    WB: 1:500~1:1000
ELISA: 1:20000
Section Bar
 Western Blot (WB) of anti-ADAM 17 antibody    Western blot analysis of extracts from K562 cells, treated with UV (5mins), using ADAM 17 (Phospho-Thr735) antibody.
anti-ADAM 17 antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ADAM 17. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.6 [Other Products]
Section Bar
 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    78,543 Da
Table BarTOPTable Bar
 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 Protein Family    ADAM 17-like protease
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
Section Bar
 NCBI Summary for ADAM 17    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
Section Bar
 UniProt Comments for ADAM 17    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Table BarTOPTable Bar
 

Product References and Citations for anti-ADAM 17 antibody

   Moss M.L., Nature 385:733-736(1997). Patel I.R., J. Immunol. 160:4570-4579(1998). Diaz-Rodriguez E., Mol. Biol. Cell 13:2031-2044(2002). Olsen J.V., Cell 127:635-648(2006).
Section Bar
 Research Articles on ADAM 17    1. Plasma levels of ADAM17 are increased in Tanzanian children hospitalized with a malaria infection compared with asymptomatic children but similar to children hospitalized with other infectious diseases. The plasma levels of ADAM17 decreased during recovery after an acute malaria episode.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ADAM 17 antibodyPathways associated with anti-ADAM 17 antibody
 Reference Product  PubMed Publications
 TNF antibody  >112 publications with ADAM 17 and TNF
 TIMP3 antibody  >18 publications with ADAM 17 and TIMP3
 NOTCH1 antibody  >8 publications with ADAM 17 and NOTCH1
 TNFSF11 antibody  >1 publications with ADAM 17 and TNFSF11
 TGFA antibody  >1 publications with ADAM 17 and TGFA
 DLG1 antibody  >1 publications with ADAM 17 and DLG1
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-ADAM 17 antibodyOrgans/Tissues associated with anti-ADAM 17 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >383 publications with ADAM 17 and Necrosis
 Neoplasms Antibodies  >118 publications with ADAM 17 and Neoplasms
 Inflammation Antibodies  >85 publications with ADAM 17 and Inflammation
 Nervous System Diseases Antibodies  >43 publications with ADAM 17 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >37 publications with ADAM 17 and Cardiovascular Diseases
 Liver Diseases Antibodies  >18 publications with ADAM 17 and Liver Diseases
 Atherosclerosis Antibodies  >15 publications with ADAM 17 and Atherosclerosis
 Lung Diseases Antibodies  >14 publications with ADAM 17 and Lung Diseases
 Kidney Diseases Antibodies  >11 publications with ADAM 17 and Kidney Diseases
 Liver Neoplasms Antibodies  >11 publications with ADAM 17 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with ADAM 17 and Brain
 Kidney Antibodies  >32 publications with ADAM 17 and Kidney
 Muscle Antibodies  >31 publications with ADAM 17 and Muscle
 Liver Antibodies  >31 publications with ADAM 17 and Liver
 Lung Antibodies  >30 publications with ADAM 17 and Lung
 Embryonic Tissue Antibodies  >26 publications with ADAM 17 and Embryonic Tissue
 Ovary Antibodies  >15 publications with ADAM 17 and Ovary
 Prostate Antibodies  >10 publications with ADAM 17 and Prostate
 Eye Antibodies  >10 publications with ADAM 17 and Eye
 Bone Marrow Antibodies  >4 publications with ADAM 17 and Bone Marrow
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions