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anti-ADCY5/6 antibody :: Rabbit ADCY5/6 Antibody

Scan QR to view Datasheet Catalog #    MBS852349
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADCY5/6, Antibody

 Also Known As   

ADCY5/6 Antibody

 Product Synonym Names    ATP pyrophosphate-lyase 5; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5
 Product Gene Name   

anti-ADCY5/6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 606703
 3D Structure    ModBase 3D Structure for O95622
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    ADCY5 antibody detects endogenous levels of total ADCY5 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human ADCY5.
 Pathway    Intermediates
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-ADCY5/6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADCY5/6 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ADCY5/6 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ADCY5/6 antibody    WB: 1:500~1:1000, ELISA: 1:10000
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 Testing Data of anti-ADCY5/6 antibody    Western blot analysis of extracts from COLO205 cells, using ADCY5 antibody.
anti-ADCY5/6 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ADCY5/6. It may not necessarily be applicable to this product.
 NCBI GI #    314122162
 NCBI GeneID    111
 NCBI Accession #    NP_001186571.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199642.1 [Other Products]
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 UniProt Primary Accession #    O95622 [Other Products]
 UniProt Secondary Accession #    Q7RTV7; Q8NFM3; B7Z8A6 [Other Products]
 UniProt Related Accession #    O95622 [Other Products]
 Molecular Weight    102,606 Da
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 NCBI Official Full Name    adenylate cyclase type 5 isoform 2
 NCBI Official Synonym Full Names    adenylate cyclase 5
 NCBI Official Symbol    ADCY5 [Similar Products]
 NCBI Official Synonym Symbols   
AC5; FDFM
[Similar Products]
 NCBI Protein Information    adenylate cyclase type 5; adenylyl cyclase 5; adenylate cyclase type V; ATP pyrophosphate-lyase 5
 UniProt Protein Name    Adenylate cyclase type 5
 UniProt Synonym Protein Names   
ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5
 UniProt Gene Name    ADCY5 [Similar Products]
 UniProt Entry Name    ADCY5_HUMAN
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 NCBI Summary for ADCY5/6    This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for ADCY5/6    ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 4.6.1.1; Adenylyl cyclase; Lyase; Transporter; Transporter, aquaporin family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein heterodimerization activity; metal ion binding; ATP binding; adenylate cyclase binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; locomotory behavior; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase inhibiting pathway; synaptic transmission; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; neuromuscular process controlling balance; transmembrane transport; adenosine receptor signaling pathway; dopamine receptor, adenylate cyclase activating pathway

Disease: Dyskinesia, Familial, With Facial Myokymia
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Product References and Citations for anti-ADCY5/6 antibody

   Muzny D.M., Nature 440:1194-1198(2006).
Ludwig M.G., J. Recept. Signal Transduct. Res. 22:79-110(2002).
Raimundo S., Clin. Chim. Acta 285:155-161(1999).
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 Research Articles on ADCY5/6    1. Alterations in beta-cell ADCY5 expression and impaired glucose signaling thus provide a likely route through which ADCY5 gene polymorphisms influence fasting glucose levels and T2D risk, while exerting more minor effects on incretin action
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADCY5/6 antibodyPathways associated with anti-ADCY5/6 antibody
 Reference Product  PubMed Publications
 ADRA2A antibody  >6 publications with ADCY5/6 and ADRA2A
 MTNR1B antibody  >6 publications with ADCY5/6 and MTNR1B
 GIPR antibody  >4 publications with ADCY5/6 and GIPR
 ADCY2 antibody  >2 publications with ADCY5/6 and ADCY2
 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
Diseases associated with anti-ADCY5/6 antibodyOrgans/Tissues associated with anti-ADCY5/6 antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >16 publications with ADCY5/6 and Diabetes Mellitus, Type 2
 Birth Weight Antibodies  >8 publications with ADCY5/6 and Birth Weight
 Nervous System Diseases Antibodies  >3 publications with ADCY5/6 and Nervous System Diseases
 Heart Diseases Antibodies  >2 publications with ADCY5/6 and Heart Diseases
 Movement Disorders Antibodies  >2 publications with ADCY5/6 and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >1 publications with ADCY5/6 and Substance Withdrawal Syndrome
 Depressive Disorder Antibodies  >1 publications with ADCY5/6 and Depressive Disorder
 Disease Models, Animal Antibodies  >1 publications with ADCY5/6 and Disease Models, Animal
 Carcinoma Antibodies  >1 publications with ADCY5/6 and Carcinoma
 Hypertension Antibodies  >1 publications with ADCY5/6 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with ADCY5/6 and Blood
 Heart Antibodies  >4 publications with ADCY5/6 and Heart
 Pancreas Antibodies  >4 publications with ADCY5/6 and Pancreas
 Nerve Antibodies  >3 publications with ADCY5/6 and Nerve
 Brain Antibodies  >3 publications with ADCY5/6 and Brain
 Lung Antibodies  >1 publications with ADCY5/6 and Lung
 Prostate Antibodies  >1 publications with ADCY5/6 and Prostate
 Placenta Antibodies  >1 publications with ADCY5/6 and Placenta
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