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anti-ADD1 antibody :: Rabbit ADD1 (Ab-445) Antibody

Scan QR to view Datasheet Catalog #    MBS003625 anti-ADD1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADD1 (Ab-445), Antibody

 Also Known As   

Rabbit ADD1 (Ab-445) Antibody

 Product Gene Name   

anti-ADD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (2845584..2931803). Location: 4p16.3
 OMIM    102680
 3D Structure    ModBase 3D Structure for P35611
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ADD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADD1 antibody   

Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ADD1. It may not necessarily be applicable to this product.
 NCBI GI #    29826319
 NCBI GeneID    118
 NCBI Accession #    NP_001110.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001119.4 [Other Products]
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 UniProt Primary Accession #    P35611 [Other Products]
 UniProt Secondary Accession #    Q13734; Q14729; Q16156; Q9UJB6; A2A3P0; D3DVR3; D3DVR4; D3DVR5 [Other Products]
 UniProt Related Accession #    P35611 [Other Products]
 Molecular Weight    80,955 Da
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 NCBI Official Full Name    alpha-adducin isoform a
 NCBI Official Synonym Full Names    adducin 1 (alpha)
 NCBI Official Symbol    ADD1 [Similar Products]
 NCBI Official Synonym Symbols   
ADDA
[Similar Products]
 NCBI Protein Information    alpha-adducin; erythrocyte adducin alpha subunit
 UniProt Protein Name    Alpha-adducin
 UniProt Synonym Protein Names   
Erythrocyte adducin subunit alpha
 Protein Family    Alpha-adducin
 UniProt Gene Name    ADD1 [Similar Products]
 UniProt Synonym Gene Names    ADDA [Similar Products]
 UniProt Entry Name    ADDA_HUMAN
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 NCBI Summary for ADD1    Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADD1    ADD1: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Three alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; F-actin capping protein complex; intermediate filament cytoskeleton; focal adhesion; perinuclear region of cytoplasm; postsynaptic density; plasma membrane; dendritic spine; cytosol; nucleus

Molecular Function: calmodulin binding; actin filament binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; T cell receptor binding; actin binding; structural molecule activity; transcription factor binding

Biological Process: actin filament bundle formation; positive regulation of protein binding; hemoglobin metabolic process; in utero embryonic development; apoptosis; unfolded protein response; multicellular organism growth; cell morphogenesis; positive regulation of endocytosis; positive regulation of angiogenesis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; homeostasis of number of cells within a tissue; erythrocyte differentiation; cell volume homeostasis; actin cytoskeleton organization and biogenesis; barbed-end actin filament capping; cell structure disassembly during apoptosis

Disease: Hypertension, Essential
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 Research Articles on ADD1    1. Variant genotype combinations of ACE and alphaADDUCIN render the hypertensive patient more vulnerable to recurrent intracerebral hemorrhage
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADD1 antibodyPathways associated with anti-ADD1 antibody
 Reference Product  PubMed Publications
 ADD2 antibody  >14 publications with ADD1 and ADD2
 ID3 antibody  >1 publications with ADD1 and ID3
 ID2 antibody  >1 publications with ADD1 and ID2
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram
Diseases associated with anti-ADD1 antibodyOrgans/Tissues associated with anti-ADD1 antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >62 publications with ADD1 and Hypertension
 Fatty Liver Antibodies  >12 publications with ADD1 and Fatty Liver
 Heart Diseases Antibodies  >12 publications with ADD1 and Heart Diseases
 Nervous System Diseases Antibodies  >10 publications with ADD1 and Nervous System Diseases
 Brain Diseases Antibodies  >9 publications with ADD1 and Brain Diseases
 Myocardial Infarction Antibodies  >6 publications with ADD1 and Myocardial Infarction
 Kidney Diseases Antibodies  >5 publications with ADD1 and Kidney Diseases
 Proteinuria Antibodies  >3 publications with ADD1 and Proteinuria
 Hemorrhage Antibodies  >3 publications with ADD1 and Hemorrhage
 Congenital Abnormalities Antibodies  >3 publications with ADD1 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >61 publications with ADD1 and Blood
 Adipose Tissue Antibodies  >31 publications with ADD1 and Adipose Tissue
 Connective Tissue Antibodies  >21 publications with ADD1 and Connective Tissue
 Liver Antibodies  >18 publications with ADD1 and Liver
 Muscle Antibodies  >14 publications with ADD1 and Muscle
 Heart Antibodies  >13 publications with ADD1 and Heart
 Kidney Antibodies  >9 publications with ADD1 and Kidney
 Brain Antibodies  >8 publications with ADD1 and Brain
 Nerve Antibodies  >5 publications with ADD1 and Nerve
 Bone Marrow Antibodies  >4 publications with ADD1 and Bone Marrow
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