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anti-ADORA1 antibody :: Rabbit anti-Human, rat ADORA1 Antibody

Scan QR to view Datasheet Catalog #    MBS003229 anti-ADORA1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADORA1, Antibody

 Also Known As   

Rabbit ADORA1 Antibody

 Product Gene Name   

anti-ADORA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (203096836..203136533). Location: 1q32.1
 OMIM    102775
 3D Structure    ModBase 3D Structure for P30542
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 Host    Rabbit
 Species Reactivity    Human, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ADORA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADORA1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ADORA1. It may not necessarily be applicable to this product.
 NCBI GI #    4501947
 NCBI GeneID    134
 NCBI Accession #    NP_000665.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000674.2 [Other Products]
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 UniProt Primary Accession #    P30542 [Other Products]
 UniProt Secondary Accession #    Q6FHK3; Q8TAM8; A6NFY5; A6NGP4; A8K1L3; B3KXQ4 [Other Products]
 UniProt Related Accession #    P30542 [Other Products]
 Molecular Weight    36,512 Da
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 NCBI Official Full Name    adenosine receptor A1
 NCBI Official Synonym Full Names    adenosine A1 receptor
 NCBI Official Symbol    ADORA1 [Similar Products]
 NCBI Official Synonym Symbols   
RDC7
[Similar Products]
 NCBI Protein Information    adenosine receptor A1
 UniProt Protein Name    Adenosine receptor A1
 Protein Family    Adenosine receptor
 UniProt Gene Name    ADORA1 [Similar Products]
 UniProt Entry Name    AA1R_HUMAN
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 NCBI Summary for ADORA1    The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADORA1    ADORA1: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Apoptosis; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: asymmetric synapse; presynaptic membrane; postsynaptic membrane; cell soma; endoplasmic reticulum; basolateral plasma membrane; integral to plasma membrane; postsynaptic density; presynaptic active zone; plasma membrane; dendritic spine; terminal button; axolemma

Molecular Function: protein binding; G-protein-coupled receptor binding; protein heterodimerization activity; G-protein beta/gamma-subunit binding; purine nucleoside binding; adenosine receptor activity, G-protein coupled; phospholipase C activity; heterotrimeric G-protein binding

Biological Process: negative regulation of circadian sleep/wake cycle, non-REM sleep; relaxation of vascular smooth muscle; activation of MAPKK activity; negative regulation of glutamate secretion; negative regulation of hormone secretion; positive regulation of potassium ion transport; regulation of synaptic plasticity; positive regulation of peptide secretion; neurological control of breathing; thermoregulation; signal transduction; positive regulation of protein amino acid dephosphorylation; negative regulation of cell proliferation; regulation of glomerular filtration; cell-cell signaling; positive regulation of nucleoside transport; positive regulation of epidermal growth factor receptor activity; negative regulation of lipid catabolic process; negative regulation of vasodilation; negative regulation of blood pressure; detection of temperature stimulus involved in sensory perception of pain; protein targeting to membrane; inflammatory response; negative regulation of synaptic transmission, GABAergic; adenosine receptor signaling pathway; nervous system development; negative regulation of neurotrophin production; negative regulation of synaptic transmission, glutamatergic; negative regulation of acute inflammatory response; negative regulation of leukocyte migration; phagocytosis; response to hypoxia; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; cognition; positive regulation of blood pressure; lipid catabolic process; negative regulation of apoptosis
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 Research Articles on ADORA1    1. ADA open form, but not the closed one, that is responsible for the functional interaction with AR and AAR.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADORA1 antibodyPathways associated with anti-ADORA1 antibody
 Reference Product  PubMed Publications
 ADA antibody  >62 publications with ADORA1 and ADA
 P2RY1 antibody  >11 publications with ADORA1 and P2RY1
 GNAI2 antibody  >2 publications with ADORA1 and GNAI2
 GNAZ antibody  >1 publications with ADORA1 and GNAZ
 Products by Pathway  Pathway Diagram
 Adenosine P1 Receptors Pathway antibodies  Adenosine P1 Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-ADORA1 antibodyOrgans/Tissues associated with anti-ADORA1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >598 publications with ADORA1 and Cardiovascular Diseases
 Ischemia Antibodies  >543 publications with ADORA1 and Ischemia
 Brain Diseases Antibodies  >415 publications with ADORA1 and Brain Diseases
 Heart Diseases Antibodies  >375 publications with ADORA1 and Heart Diseases
 Myocardial Ischemia Antibodies  >299 publications with ADORA1 and Myocardial Ischemia
 Inflammation Antibodies  >162 publications with ADORA1 and Inflammation
 Pain Antibodies  >157 publications with ADORA1 and Pain
 Brain Ischemia Antibodies  >155 publications with ADORA1 and Brain Ischemia
 Seizures Antibodies  >147 publications with ADORA1 and Seizures
 Kidney Diseases Antibodies  >143 publications with ADORA1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1816 publications with ADORA1 and Brain
 Heart Antibodies  >894 publications with ADORA1 and Heart
 Muscle Antibodies  >702 publications with ADORA1 and Muscle
 Kidney Antibodies  >391 publications with ADORA1 and Kidney
 Eye Antibodies  >134 publications with ADORA1 and Eye
 Lung Antibodies  >114 publications with ADORA1 and Lung
 Liver Antibodies  >97 publications with ADORA1 and Liver
 Connective Tissue Antibodies  >72 publications with ADORA1 and Connective Tissue
 Ovary Antibodies  >68 publications with ADORA1 and Ovary
 Embryonic Tissue Antibodies  >51 publications with ADORA1 and Embryonic Tissue
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