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anti-AGTR1 antibody :: Rabbit AGTR1 Antibody

Scan QR to view Datasheet Catalog #    MBS004393 anti-AGTR1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AGTR1, Antibody

 Also Known As   

Rabbit AGTR1 Antibody

 Product Gene Name   

anti-AGTR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (148415658..148460790). Location: 3q24
 OMIM    106165
 3D Structure    ModBase 3D Structure for P30556
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-AGTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AGTR1 antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for AGTR1. It may not necessarily be applicable to this product.
 NCBI GI #    4501997
 NCBI GeneID    185
 NCBI Accession #    NP_000676.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000685.4 [Other Products]
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 UniProt Primary Accession #    P30556 [Other Products]
 UniProt Secondary Accession #    Q13725 [Other Products]
 UniProt Related Accession #    P30556 [Other Products]
 Molecular Weight    41,061 Da
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 NCBI Official Full Name    type-1 angiotensin II receptor isoform 1
 NCBI Official Synonym Full Names    angiotensin II receptor, type 1
 NCBI Official Symbol    AGTR1 [Similar Products]
 NCBI Official Synonym Symbols   
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1A; AGTR1B; AT2R1A; AT2R1B
[Similar Products]
 NCBI Protein Information    type-1 angiotensin II receptor; type-1B angiotensin II receptor
 UniProt Protein Name    Type-1 angiotensin II receptor
 UniProt Synonym Protein Names   
AT1AR; AT1BR; Angiotensin II type-1 receptor
 Protein Family    Type-1 angiotensin II receptor
 UniProt Gene Name    AGTR1 [Similar Products]
 UniProt Synonym Gene Names    AGTR1A; AGTR1B; AT2R1; AT2R1B; AT1 [Similar Products]
 UniProt Entry Name    AGTR1_HUMAN
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 NCBI Summary for AGTR1    Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for AGTR1    AT1: receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. Mediates the major cardiovascular effects of angiotensin II. May play role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; angiotensin type II receptor activity; protein heterodimerization activity; angiotensin type I receptor activity; bradykinin receptor binding

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of vasodilation; positive regulation of cellular protein metabolic process; renin-angiotensin regulation of aldosterone production; calcium-mediated signaling; regulation of systemic arterial blood pressure by renin-angiotensin; Rho protein signal transduction; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; renin-angiotensin regulation of blood vessel size; regulation of vasoconstriction; regulation of inflammatory response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of cell growth; kidney development; positive regulation of phospholipase A2 activity; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity

Disease: Renal Tubular Dysgenesis; Hypertension, Essential
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 Research Articles on AGTR1    1. A novel observation was that resistance to angiotensin receptor blocker binding to opossum AT(1)Rs correlates with variations from the human receptor at positions 108, 163, 192, and 198 within the ARB-binding pocket.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AGTR1 antibodyDiseases associated with anti-AGTR1 antibody
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >100 publications with AGTR1 and Vascular Diseases
 Hypertension Antibodies  >88 publications with AGTR1 and Hypertension
 Heart Diseases Antibodies  >58 publications with AGTR1 and Heart Diseases
 Kidney Diseases Antibodies  >33 publications with AGTR1 and Kidney Diseases
 Atherosclerosis Antibodies  >22 publications with AGTR1 and Atherosclerosis
 Hypertrophy Antibodies  >17 publications with AGTR1 and Hypertrophy
 Inflammation Antibodies  >15 publications with AGTR1 and Inflammation
 Diabetic Nephropathies Antibodies  >15 publications with AGTR1 and Diabetic Nephropathies
 Hypertrophy, Left Ventricular Antibodies  >14 publications with AGTR1 and Hypertrophy, Left Ventricular
 Myocardial Infarction Antibodies  >14 publications with AGTR1 and Myocardial Infarction
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