NP_001278407.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
65,230 Da
NCBI Official Full Name
A-kinase anchor protein 8-like isoform 2
NCBI Official Synonym Full Names
A-kinase anchoring protein 8 like
NCBI Protein Information
A-kinase anchor protein 8-like
UniProt Protein Name
A-kinase anchor protein 8-like
UniProt Synonym Protein Names
Helicase A-binding protein 95; HAP95; Homologous to AKAP95 protein; HA95; Neighbor of A-kinase-anchoring protein 95; Neighbor of AKAP95
UniProt Synonym Gene Names
NAKAP; NAKAP95; AKAP8-like protein; HAP95; HA95; Neighbor of AKAP95 [Similar Products]
UniProt Comments for AKAP8L
Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).
Research Articles on AKAP8L
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Products associated with anti-AKAP8L antibody
Pathways associated with anti-AKAP8L antibody
Diseases associated with anti-AKAP8L antibody
Organs/Tissues associated with anti-AKAP8L antibody
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