NP_000026.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,473 Da
NCBI Official Full Name
fructose-bisphosphate aldolase B
NCBI Official Synonym Full Names
aldolase B, fructose-bisphosphate
NCBI Official Synonym Symbols
NCBI Protein Information
fructose-bisphosphate aldolase B; aldolase 2; liver-type aldolase; aldolase B, fructose-bisphosphatase
UniProt Protein Name
Fructose-bisphosphate aldolase B
UniProt Synonym Protein Names
Liver-type aldolase
UniProt Synonym Gene Names
UniProt Entry Name
ALDOB_HUMAN
NCBI Summary for ALDOB
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]
UniProt Comments for ALDOB
ALDOB: Defects in ALDOB are the cause of hereditary fructose intolerance (HFI). HFI is an autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. Belongs to the class I fructose-bisphosphate aldolase family.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; EC 4.1.2.13; Lyase; Carbohydrate Metabolism - pentose phosphate pathway
Chromosomal Location of Human Ortholog: 9q21.3-q22.2
Cellular Component: microtubule organizing center; cytosol
Molecular Function: identical protein binding; protein binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; ATPase binding
Biological Process: fructose 1,6-bisphosphate metabolic process; NADH oxidation; glycolysis; positive regulation of ATPase activity; carbohydrate metabolic process; glucose metabolic process; pathogenesis; fructose catabolic process; gluconeogenesis; fructose metabolic process
Disease: Fructose Intolerance, Hereditary
Research Articles on ALDOB
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Pathways associated with anti-ALDOB antibody
Diseases associated with anti-ALDOB antibody
Organs/Tissues associated with anti-ALDOB antibody
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