NP_004295.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,442 Da
NCBI Official Full Name
ALK tyrosine kinase receptor isoform 1
NCBI Official Synonym Full Names
ALK receptor tyrosine kinase
NCBI Protein Information
ALK tyrosine kinase receptor
UniProt Protein Name
ALK tyrosine kinase receptor
UniProt Synonym Protein Names
Anaplastic lymphoma kinase; CD_antigen: CD246
NCBI Summary for ALK
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
UniProt Comments for ALK
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
Product References and Citations for anti-ALK antibody
Morris S.W., Oncogene 14:2175-2188(1997). Hillier L.W., Nature 434:724-731(2005). Simonitsch I., FASEB J. 15:1416-1418(2001).
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Products associated with anti-ALK antibody
Diseases associated with anti-ALK antibody
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>1531 publications with ALK and Neoplasms |
Immune System Diseases Antibodies |
>967 publications with ALK and Immune System Diseases |
Lymphoma, Large-Cell, Anaplastic Antibodies |
>882 publications with ALK and Lymphoma, Large-Cell, Anaplastic |
Respiratory Tract Diseases Antibodies |
>529 publications with ALK and Respiratory Tract Diseases |
Lung Diseases Antibodies |
>446 publications with ALK and Lung Diseases |
Lymphoma, Large B-Cell, Diffuse Antibodies |
>317 publications with ALK and Lymphoma, Large B-Cell, Diffuse |
Carcinoma, Non-Small-Cell Lung Antibodies |
>269 publications with ALK and Carcinoma, Non-Small-Cell Lung |
Neuroblastoma Antibodies |
>133 publications with ALK and Neuroblastoma |
Death Antibodies |
>99 publications with ALK and Death |
Neoplasms, Experimental Antibodies |
>96 publications with ALK and Neoplasms, Experimental |
Organs/Tissues associated with anti-ALK antibody
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