NP_001273035.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,931 Da
NCBI Official Full Name
autophagy protein 5 isoform a
NCBI Official Synonym Full Names
autophagy related 5
NCBI Official Synonym Symbols
ASP; APG5; APG5L; hAPG5; SCAR25; APG5-LIKE [Similar Products]
NCBI Protein Information
autophagy protein 5
UniProt Protein Name
Autophagy protein 5
UniProt Synonym Protein Names
APG5-like; Apoptosis-specific protein
UniProt Synonym Gene Names
NCBI Summary for APG5L/ATG5
The protein encoded by this gene, in combination with autophagy protein 12, functions as an E1-like activating enzyme in a ubiquitin-like conjugating system. The encoded protein is involved in several cellular processes, including autophagic vesicle formation, mitochondrial quality control after oxidative damage, negative regulation of the innate antiviral immune response, lymphocyte development and proliferation, MHC II antigen presentation, adipocyte differentiation, and apoptosis. Several transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for APG5L/ATG5
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
Research Articles on APG5L/ATG5
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Products associated with anti-APG5L/ATG5 antibody
Pathways associated with anti-APG5L/ATG5 antibody
Diseases associated with anti-APG5L/ATG5 antibody
Organs/Tissues associated with anti-APG5L/ATG5 antibody
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