NP_000032.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,154 Da
NCBI Official Full Name
apolipoprotein E isoform b
NCBI Official Synonym Full Names
apolipoprotein E
NCBI Protein Information
apolipoprotein E
UniProt Protein Name
Apolipoprotein E
UniProt Synonym Gene Names
NCBI Summary for APOE
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]
UniProt Comments for APOE
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Product References and Citations for anti-APOE antibody
Zannis V.I., J. Biol. Chem. 259:5495-5499(1984). McLean J.W., J. Biol. Chem. 259:6498-6504(1984). Paik Y.-K., Proc. Natl. Acad. Sci. U.S.A. 82:3445-3449(1985).
Research Articles on APOE
Precautions
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Disclaimer
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Products associated with anti-APOE antibody
Pathways associated with anti-APOE antibody
Diseases associated with anti-APOE antibody
Organs/Tissues associated with anti-APOE antibody
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