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anti-ARC antibody :: Rabbit ARC (CT) Antibody

Scan QR to view Datasheet Catalog #    MBS194026 anti-ARC antibody
Unit / Price
0.1 mg  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARC (CT), Antibody

 Also Known As   

Anti-ARC (CT) Antibody

 Product Synonym Names    Anti-ARC (CT); ARC (CT)
 Product Gene Name   

anti-ARC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612461
 3D Structure    ModBase 3D Structure for Q7LC44
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 Host    Rabbit
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 Specificity    Anti-ARC (CT) [Rabbit antibody to peptide corresponding to aa 191-208 at C-terminus of human apoptosis repressor with CARD (ARC).]
This antibody recognizes full-length ARC (25 kD).
 Form/Format    100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
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 Antigen    Peptide corresponding to aa 191-208 of human ARC.
 Stabilizer    None
 Preservatives    0.02% sodium azide.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -20 degree C. Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of anti-ARC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ARC antibody

   Apoptosis is regulated by death domain (DD)- and/or caspase recruitment domain (CARD)-containing molecules and a caspase family of proteases. CARD domain-containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain-containing protein was recently identified and designated ARC (apoptosis repressor with CARD). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR- 1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
 Product Categories/Family for anti-ARC antibody    Apoptosis Antibodies
 Applications Tested/Suitable for anti-ARC antibody   

Immunoblot

 Application Notes for anti-ARC antibody    Immunoblotting: use at 1:1,000 dilution.
Positive control: Whole cell lysate of HeLa, KB, and A549 cells.
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NCBI/Uniprot data below describe general gene information for ARC. It may not necessarily be applicable to this product.
 NCBI GI #    6319152
 NCBI GeneID    23237
 NCBI Accession #    AAF07185.1 [Other Products]
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 UniProt Primary Accession #    Q7LC44 [Other Products]
 UniProt Secondary Accession #    Q9UJW6; Q9Y469 [Other Products]
 UniProt Related Accession #    Q7LC44 [Other Products]
 Molecular Weight    45,316 Da [Similar Products]
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 NCBI Official Full Name    ARC
 NCBI Official Synonym Full Names    activity-regulated cytoskeleton-associated protein
 NCBI Official Symbol    ARC [Similar Products]
 NCBI Official Synonym Symbols   
Arg3.1; KIAA0278; ARC
[Similar Products]
 NCBI Protein Information    activity-regulated cytoskeleton-associated protein
 UniProt Protein Name    Activity-regulated cytoskeleton-associated protein
 UniProt Synonym Protein Names   
ARC/ARG3.1; Activity-regulated gene 3.1 protein homolog
 Protein Family    AAA ATPase forming ring-shaped complexes
 UniProt Gene Name    ARC [Similar Products]
 UniProt Synonym Gene Names    KIAA0278 [Similar Products]
 UniProt Entry Name    ARC_HUMAN
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 UniProt Comments for ARC    ARG3.1: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. Belongs to the ARC/ARG3.1 family.

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: postsynaptic membrane; cytoplasm; postsynaptic density; dendritic spine; acrosome; plasma membrane; cell junction; endosome; actin cytoskeleton

Biological Process: anterior/posterior pattern formation; cell migration; regulation of cell morphogenesis; cytoskeleton organization and biogenesis; endocytosis; learning; endoderm development; regulation of neuronal synaptic plasticity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ARC antibodyDiseases associated with anti-ARC antibody
 Products by Pathway  Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Disease Name  Pubmed Publications
 Pain Antibodies  >637 publications with ARC and Pain
 Mental Disorders Antibodies  >338 publications with ARC and Mental Disorders
 Lung Diseases Antibodies  >324 publications with ARC and Lung Diseases
 Obesity Antibodies  >216 publications with ARC and Obesity
 Genetic Diseases, Inborn Antibodies  >194 publications with ARC and Genetic Diseases, Inborn
 Genital Diseases, Male Antibodies  >183 publications with ARC and Genital Diseases, Male
 Inflammation Antibodies  >162 publications with ARC and Inflammation
 Weight Loss Antibodies  >124 publications with ARC and Weight Loss
 Prostatic Diseases Antibodies  >123 publications with ARC and Prostatic Diseases
 Kidney Diseases Antibodies  >110 publications with ARC and Kidney Diseases
Organs/Tissues associated with anti-ARC antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2293 publications with ARC and Brain
 Blood Antibodies  >2245 publications with ARC and Blood
 Bone Antibodies  >1237 publications with ARC and Bone
 Eye Antibodies  >1087 publications with ARC and Eye
 Lung Antibodies  >387 publications with ARC and Lung
 Liver Antibodies  >182 publications with ARC and Liver
 Prostate Antibodies  >156 publications with ARC and Prostate
 Adrenal Gland Antibodies  >38 publications with ARC and Adrenal Gland
 Placenta Antibodies  >15 publications with ARC and Placenta
 Uncharacterized Tissue Antibodies  >3 publications with ARC and Uncharacterized Tissue
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