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anti-ARFGEF2 antibody :: Rabbit ARFGEF2 Antibody

Scan QR to view Datasheet Catalog #    MBS003186 anti-ARFGEF2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARFGEF2, Antibody

 Also Known As   

Rabbit ARFGEF2 Antibody

 Product Gene Name   

anti-ARFGEF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (47538275..47653230). Location: 20q13.13
 OMIM    605371
 3D Structure    ModBase 3D Structure for Q9Y6D5
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ARFGEF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARFGEF2 antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ARFGEF2. It may not necessarily be applicable to this product.
 NCBI GI #    150417986
 NCBI GeneID    10564
 NCBI Accession #    NP_006411.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006420.2 [Other Products]
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 UniProt Primary Accession #    Q9Y6D5 [Other Products]
 UniProt Secondary Accession #    Q5TFT9; Q9NTS1 [Other Products]
 UniProt Related Accession #    Q9Y6D5 [Other Products]
 Molecular Weight    202,038 Da
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 NCBI Official Full Name    brefeldin A-inhibited guanine nucleotide-exchange protein 2
 NCBI Official Synonym Full Names    ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
 NCBI Official Symbol    ARFGEF2 [Similar Products]
 NCBI Official Synonym Symbols   
BIG2; PVNH2; dJ1164I10.1
[Similar Products]
 NCBI Protein Information    brefeldin A-inhibited guanine nucleotide-exchange protein 2; brefeldin A-inhibited GEP 2
 UniProt Protein Name    Brefeldin A-inhibited guanine nucleotide-exchange protein 2
 UniProt Synonym Protein Names   
ADP-ribosylation factor guanine nucleotide-exchange factor 2
 UniProt Gene Name    ARFGEF2 [Similar Products]
 UniProt Synonym Gene Names    ARFGEP2; BIG2; Brefeldin A-inhibited GEP 2 [Similar Products]
 UniProt Entry Name    BIG2_HUMAN
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 NCBI Summary for ARFGEF2    ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ARFGEF2    ARFGEF2: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Defects in ARFGEF2 are the cause of autosomal recessive periventricular nodular heterotopia type 2 (PVNH2); also known as periventricular heterotopia with microcephaly autosomal recessive. PVNH is a developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.

Protein type: GEFs, ARF; GEFs

Chromosomal Location of Human Ortholog: 20q13.13

Cellular Component: Golgi membrane; asymmetric synapse; recycling endosome; membrane; perinuclear region of cytoplasm; cytoplasmic membrane-bound vesicle; dendritic spine; microtubule organizing center; cytoplasmic vesicle; trans-Golgi network; cell junction; cytosol

Molecular Function: protein binding; myosin binding; guanyl-nucleotide exchange factor activity; GABA receptor binding; ARF guanyl-nucleotide exchange factor activity

Biological Process: vesicle-mediated transport; receptor recycling; Golgi to plasma membrane transport; protein transport; exocytosis; endosome organization and biogenesis; endomembrane organization; regulation of ARF protein signal transduction; positive regulation of tumor necrosis factor production; positive regulation of GTPase activity

Disease: Periventricular Heterotopia With Microcephaly, Autosomal Recessive
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 Research Articles on ARFGEF2    1. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARFGEF2 antibodyPathways associated with anti-ARFGEF2 antibody
 Reference Product  PubMed Publications
 ARFGEF1 antibody  >14 publications with ARFGEF2 and ARFGEF1
 PRKAR1A antibody  >1 publications with ARFGEF2 and PRKAR1A
 Products by Pathway  Pathway Diagram
 Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies  Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
Diseases associated with anti-ARFGEF2 antibodyOrgans/Tissues associated with anti-ARFGEF2 antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >5 publications with ARFGEF2 and Brain Diseases
 Necrosis Antibodies  >2 publications with ARFGEF2 and Necrosis
 Pancreatitis Antibodies  >1 publications with ARFGEF2 and Pancreatitis
 Neurodegenerative Diseases Antibodies  >1 publications with ARFGEF2 and Neurodegenerative Diseases
 Liver Neoplasms Antibodies  >1 publications with ARFGEF2 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with ARFGEF2 and Liver Diseases
 Learning Disorders Antibodies  >1 publications with ARFGEF2 and Learning Disorders
 Seizures Antibodies  >1 publications with ARFGEF2 and Seizures
 Inflammation Antibodies  >1 publications with ARFGEF2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with ARFGEF2 and Brain
 Blood Antibodies  >10 publications with ARFGEF2 and Blood
 Heart Antibodies  >7 publications with ARFGEF2 and Heart
 Lung Antibodies  >7 publications with ARFGEF2 and Lung
 Nerve Antibodies  >3 publications with ARFGEF2 and Nerve
 Embryonic Tissue Antibodies  >3 publications with ARFGEF2 and Embryonic Tissue
 Vascular Antibodies  >2 publications with ARFGEF2 and Vascular
 Liver Antibodies  >2 publications with ARFGEF2 and Liver
 Kidney Antibodies  >2 publications with ARFGEF2 and Kidney
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