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anti-ARHGDIA antibody :: Rabbit ARHGDIA (Phospho-Ser174) Antibody

Scan QR to view Datasheet Catalog #    MBS001291 anti-ARHGDIA antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGDIA (Phospho-Ser174), Antibody

 Also Known As   

Rabbit ARHGDIA (Phospho-Ser174) Antibody

 Product Gene Name   

anti-ARHGDIA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (79825597..79829282, complement). Location: 17q25.3
 OMIM    601925
 3D Structure    ModBase 3D Structure for P52565
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ARHGDIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARHGDIA antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ARHGDIA. It may not necessarily be applicable to this product.
 NCBI GI #    297374782
 NCBI GeneID    396
 NCBI Accession #    NP_001172006.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001185077.1 [Other Products]
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 UniProt Primary Accession #    P52565 [Other Products]
 UniProt Secondary Accession #    Q6IBM5; B2R5X1 [Other Products]
 UniProt Related Accession #    P52565 [Other Products]
 Molecular Weight    23,207 Da
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 NCBI Official Full Name    rho GDP-dissociation inhibitor 1 isoform a
 NCBI Official Synonym Full Names    Rho GDP dissociation inhibitor (GDI) alpha
 NCBI Official Symbol    ARHGDIA [Similar Products]
 NCBI Official Synonym Symbols   
GDIA1; NPHS8; RHOGDI; RHOGDI-1
[Similar Products]
 NCBI Protein Information    rho GDP-dissociation inhibitor 1; rho GDI 1; rho-GDI alpha
 UniProt Protein Name    Rho GDP-dissociation inhibitor 1
 UniProt Synonym Protein Names   
Rho-GDI alpha
 UniProt Gene Name    ARHGDIA [Similar Products]
 UniProt Synonym Gene Names    GDIA1; Rho GDI 1 [Similar Products]
 UniProt Entry Name    GDIR1_HUMAN
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 NCBI Summary for ARHGDIA    Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]
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 UniProt Comments for ARHGDIA    RhoGDI alpha: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Monomer. Forms a heterodimer with RAC1. Interacts with FER. Belongs to the Rho GDI family.

Protein type: Cell adhesion; G protein regulator, misc.; Apoptosis; Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: cytoskeleton; immunological synapse; cytosol

Molecular Function: protein binding; Rho GDP-dissociation inhibitor activity; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; regulation of protein localization; nerve growth factor receptor signaling pathway; small GTPase mediated signal transduction; negative regulation of axonogenesis; positive regulation of axonogenesis; negative regulation of cell adhesion; cell motility; regulation of axonogenesis; negative regulation of cell migration; Rho protein signal transduction; negative regulation of apoptosis; positive regulation of GTPase activity

Disease: Nephrotic Syndrome, Type 8
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 Research Articles on ARHGDIA    1. demonstrate that membrane extraction of Rho GTPase by RhoGDI is a thermodynamically favored passive process that operates through a series of progressively tighter intermediates, much like the one that is mediated by RabGDI
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARHGDIA antibodyPathways associated with anti-ARHGDIA antibody
 Reference Product  PubMed Publications
 RHOA antibody  >40 publications with ARHGDIA and RHOA
 RAC1 antibody  >28 publications with ARHGDIA and RAC1
 CDC42 antibody  >25 publications with ARHGDIA and CDC42
 PAK1 antibody  >6 publications with ARHGDIA and PAK1
 RAC2 antibody  >2 publications with ARHGDIA and RAC2
 VAV1 antibody  >1 publications with ARHGDIA and VAV1
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
Diseases associated with anti-ARHGDIA antibodyOrgans/Tissues associated with anti-ARHGDIA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >32 publications with ARHGDIA and Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with ARHGDIA and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >5 publications with ARHGDIA and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >4 publications with ARHGDIA and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >4 publications with ARHGDIA and Breast Neoplasms
 Brain Diseases Antibodies  >3 publications with ARHGDIA and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with ARHGDIA and Nervous System Diseases
 Lung Diseases Antibodies  >3 publications with ARHGDIA and Lung Diseases
 Proteinuria Antibodies  >3 publications with ARHGDIA and Proteinuria
 Kidney Diseases Antibodies  >2 publications with ARHGDIA and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >7 publications with ARHGDIA and Muscle
 Blood Antibodies  >6 publications with ARHGDIA and Blood
 Brain Antibodies  >6 publications with ARHGDIA and Brain
 Lung Antibodies  >4 publications with ARHGDIA and Lung
 Kidney Antibodies  >3 publications with ARHGDIA and Kidney
 Bone Marrow Antibodies  >3 publications with ARHGDIA and Bone Marrow
 Vascular Antibodies  >3 publications with ARHGDIA and Vascular
 Heart Antibodies  >3 publications with ARHGDIA and Heart
 Bone Antibodies  >3 publications with ARHGDIA and Bone
 Eye Antibodies  >2 publications with ARHGDIA and Eye
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