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anti-ARHGDIA antibody :: ARHGDIA Antibody

Scan QR to view Datasheet Catalog #    MBS859500
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGDIA, Antibody

★Popular Item★
 Also Known As   

ARHGDIA (Phospho-Ser174) Antibody

 Product Synonym Names    GDIR; Rho GDI 1; Rho GDP-dissociation inhibitor 1; Rho-GDI alpha
 Product Gene Name   

anti-ARHGDIA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601925
 3D Structure    ModBase 3D Structure for P52565
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    ARHGDIA (Phospho-Ser174) antibody detects endogenous levels of ARHGDIA only when phosphorylated at serine 174.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human ARHGDIA around the phosphorylation site of serine 174 (R-G-SP-Y-S).
 All Sites    Human: Ser174
Mouse: Ser174
Rat: Ser174
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-ARHGDIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ARHGDIA antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ARHGDIA antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-ARHGDIA antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
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 Testing Data of anti-ARHGDIA antibody    P-peptide-+
anti-ARHGDIA antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-ARHGDIA antibody    Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using ARHGDIA (Phospho-Ser174) antibody. Western blot analysis of extracts from HUVEC cells, treated with EGF (200ng/ml, 30mins), using ARHGDIA (Phospho-Ser174) antibody.
anti-ARHGDIA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ARHGDIA. It may not necessarily be applicable to this product.
 NCBI GI #    297374782
 NCBI GeneID    396
 NCBI Accession #    NP_001172006.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001185077.2 [Other Products]
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 UniProt Primary Accession #    P52565 [Other Products]
 UniProt Secondary Accession #    Q6IBM5; A8MXW0; B2R5X1; B4DDD3; B4DUV9 [Other Products]
 UniProt Related Accession #    P52565 [Other Products]
 Molecular Weight    18,233 Da
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 NCBI Official Full Name    rho GDP-dissociation inhibitor 1 isoform a
 NCBI Official Synonym Full Names    Rho GDP dissociation inhibitor alpha
 NCBI Official Symbol    ARHGDIA [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    rho GDP-dissociation inhibitor 1
 UniProt Protein Name    Rho GDP-dissociation inhibitor 1
 UniProt Synonym Protein Names   
Rho-GDI alpha
 UniProt Gene Name    ARHGDIA [Similar Products]
 UniProt Synonym Gene Names    GDIA1; Rho GDI 1 [Similar Products]
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 NCBI Summary for ARHGDIA    This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for ARHGDIA    Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
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Product References and Citations for anti-ARHGDIA antibody

   Leffers H., Exp. Cell Res. 209:165-174(1993). Maeda A., Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases. Chuang T.H., Submitted (JUL-1992) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on ARHGDIA    1. RhoGDIalpha is involved in the maintenance of glioma stem cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARHGDIA antibodyPathways associated with anti-ARHGDIA antibody
 Reference Product  PubMed Publications
 RHOA antibody  >40 publications with ARHGDIA and RHOA
 RAC1 antibody  >28 publications with ARHGDIA and RAC1
 CDC42 antibody  >25 publications with ARHGDIA and CDC42
 PAK1 antibody  >6 publications with ARHGDIA and PAK1
 RAC2 antibody  >2 publications with ARHGDIA and RAC2
 VAV1 antibody  >1 publications with ARHGDIA and VAV1
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Regulation Of CDC42 Activity Pathway antibodies  Regulation Of CDC42 Activity Pathway Diagram
 Regulation Of RAC1 Activity Pathway antibodies  Regulation Of RAC1 Activity Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
Diseases associated with anti-ARHGDIA antibodyOrgans/Tissues associated with anti-ARHGDIA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >32 publications with ARHGDIA and Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with ARHGDIA and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >5 publications with ARHGDIA and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >4 publications with ARHGDIA and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >4 publications with ARHGDIA and Breast Neoplasms
 Brain Diseases Antibodies  >3 publications with ARHGDIA and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with ARHGDIA and Nervous System Diseases
 Lung Diseases Antibodies  >3 publications with ARHGDIA and Lung Diseases
 Proteinuria Antibodies  >3 publications with ARHGDIA and Proteinuria
 Kidney Diseases Antibodies  >2 publications with ARHGDIA and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >7 publications with ARHGDIA and Muscle
 Blood Antibodies  >6 publications with ARHGDIA and Blood
 Brain Antibodies  >6 publications with ARHGDIA and Brain
 Lung Antibodies  >4 publications with ARHGDIA and Lung
 Kidney Antibodies  >3 publications with ARHGDIA and Kidney
 Bone Marrow Antibodies  >3 publications with ARHGDIA and Bone Marrow
 Vascular Antibodies  >3 publications with ARHGDIA and Vascular
 Heart Antibodies  >3 publications with ARHGDIA and Heart
 Bone Antibodies  >3 publications with ARHGDIA and Bone
 Eye Antibodies  >2 publications with ARHGDIA and Eye
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