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anti-ARHGEF1 antibody :: Rabbit ARHGEF1 Antibody

Scan QR to view Datasheet Catalog #    MBS003180 anti-ARHGEF1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARHGEF1, Antibody

 Also Known As   

Rabbit ARHGEF1 Antibody

 Product Gene Name   

anti-ARHGEF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (42387267..42411604). Location: 19q13.13
 OMIM    601855
 3D Structure    ModBase 3D Structure for Q92888
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-ARHGEF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ARHGEF1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ARHGEF1. It may not necessarily be applicable to this product.
 NCBI GI #    15011972
 NCBI GeneID    9138
 NCBI Accession #    NP_004697.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004706.3 [Other Products]
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 UniProt Primary Accession #    Q92888 [Other Products]
 UniProt Secondary Accession #    O00513; Q8N4J4; Q96BF4; Q96F17; Q9BSB1 [Other Products]
 UniProt Related Accession #    Q92888 [Other Products]
 Molecular Weight    102,435 Da
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 NCBI Official Full Name    rho guanine nucleotide exchange factor 1 isoform 2
 NCBI Official Synonym Full Names    Rho guanine nucleotide exchange factor (GEF) 1
 NCBI Official Symbol    ARHGEF1 [Similar Products]
 NCBI Official Synonym Symbols   
LSC; GEF1; LBCL2; SUB1.5; P115-RHOGEF
[Similar Products]
 NCBI Protein Information    rho guanine nucleotide exchange factor 1; p115RhoGEF; Lsc homolog; 115-kD protein; 115 kDa guanine nucleotide exchange factor
 UniProt Protein Name    Rho guanine nucleotide exchange factor 1
 UniProt Synonym Protein Names   
115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
 Protein Family    Rho guanine nucleotide exchange factor
 UniProt Gene Name    ARHGEF1 [Similar Products]
 UniProt Synonym Gene Names    p115-RhoGEF; p115RhoGEF [Similar Products]
 UniProt Entry Name    ARHG1_HUMAN
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 NCBI Summary for ARHGEF1    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ARHGEF1    ARHGEF1: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2- induced RhoA activation. Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1. Interacts with CTNNAL1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.13

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; GTPase activator activity

Biological Process: cell proliferation; nerve growth factor receptor signaling pathway; negative regulation of axonogenesis; regulation of axonogenesis; Rho protein signal transduction
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 Research Articles on ARHGEF1    1. High GEF1 expression is associated with metastasis of pancreatic cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ARHGEF1 antibodyPathways associated with anti-ARHGEF1 antibody
 Reference Product  PubMed Publications
 PRKCA antibody  >2 publications with ARHGEF1 and PRKCA
 CNKSR1 antibody  >2 publications with ARHGEF1 and CNKSR1
 CD44 antibody  >2 publications with ARHGEF1 and CD44
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Proteoglycans In Cancer Pathway antibodies  Proteoglycans In Cancer Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of RhoA Activity Pathway antibodies  Regulation Of RhoA Activity Pathway Diagram
Diseases associated with anti-ARHGEF1 antibodyOrgans/Tissues associated with anti-ARHGEF1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >62 publications with ARHGEF1 and Neoplasms
 Cardiovascular Diseases Antibodies  >20 publications with ARHGEF1 and Cardiovascular Diseases
 Inflammation Antibodies  >9 publications with ARHGEF1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >9 publications with ARHGEF1 and Neurobehavioral Manifestations
 Disease Models, Animal Antibodies  >9 publications with ARHGEF1 and Disease Models, Animal
 Brain Diseases Antibodies  >9 publications with ARHGEF1 and Brain Diseases
 Hypertrophy Antibodies  >7 publications with ARHGEF1 and Hypertrophy
 Heart Diseases Antibodies  >6 publications with ARHGEF1 and Heart Diseases
 Liver Diseases Antibodies  >4 publications with ARHGEF1 and Liver Diseases
 Kidney Diseases Antibodies  >3 publications with ARHGEF1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >58 publications with ARHGEF1 and Blood
 Brain Antibodies  >49 publications with ARHGEF1 and Brain
 Muscle Antibodies  >43 publications with ARHGEF1 and Muscle
 Vascular Antibodies  >33 publications with ARHGEF1 and Vascular
 Kidney Antibodies  >31 publications with ARHGEF1 and Kidney
 Nerve Antibodies  >30 publications with ARHGEF1 and Nerve
 Embryonic Tissue Antibodies  >18 publications with ARHGEF1 and Embryonic Tissue
 Lung Antibodies  >16 publications with ARHGEF1 and Lung
 Bone Antibodies  >11 publications with ARHGEF1 and Bone
 Liver Antibodies  >10 publications with ARHGEF1 and Liver
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