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anti-ATF-2 antibody :: Rabbit ATF-2 Antibody

Scan QR to view Datasheet Catalog #    MBS853080
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATF-2, Antibody

 Also Known As   

ATF-2 (Ab-472) Antibody

 Product Synonym Names    Activating 2; ATF2; cAMP response element binding protein CRE- BP1; CREB2; CREBP1; Cyclic-AMP-dependent ATF-2; HB16; MXBP protein
 Product Gene Name   

anti-ATF-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123811
 3D Structure    ModBase 3D Structure for P15336
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    ATF-2 (Ab-472) antibody detects endogenous levels of total ATF-2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human ATF-2 around the phosphorylation site of serine 472 (A-L-SP-Q-I).
 Pathway    Transcription
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-ATF-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ATF-2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-ATF-2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ATF-2 antibody    WB: 1:500~1:1000, ELISA: 1:20000
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 Testing Data of anti-ATF-2 antibody    Western blot analysis of extracts from HeLa cells and 293 cells, using ATF-2 (Ab-472) antibody.
anti-ATF-2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for ATF-2. It may not necessarily be applicable to this product.
 NCBI GI #    368711269
 NCBI GeneID    1386
 NCBI Accession #    NP_001243019.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256090.1 [Other Products]
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 UniProt Primary Accession #    P15336 [Other Products]
 UniProt Secondary Accession #    Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5 [Other Products]
 UniProt Related Accession #    P15336 [Other Products]
 Molecular Weight    15,409 Da
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 NCBI Official Full Name    cyclic AMP-dependent transcription factor ATF-2 isoform 1
 NCBI Official Synonym Full Names    activating transcription factor 2
 NCBI Official Symbol    ATF2 [Similar Products]
 NCBI Official Synonym Symbols   
HB16; CREB2; TREB7; CREB-2; CRE-BP1
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-2; histone acetyltransferase ATF2; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cAMP response element-binding protein CRE-BP1; cyclic AMP-responsive element-binding protein 2; cAMP responsive element binding protein 2, formerly; activating transcription factor 2 splice variant ATF2-var2
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-2
 UniProt Synonym Protein Names   
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
 UniProt Gene Name    ATF2 [Similar Products]
 UniProt Synonym Gene Names    CREB2; CREBP1; cAMP-dependent transcription factor ATF-2; CREB-2; cAMP-responsive element-binding protein 2 [Similar Products]
 UniProt Entry Name    ATF2_HUMAN
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 NCBI Summary for ATF-2    This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
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 UniProt Comments for ATF-2    ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.

Protein type: EC 2.3.1.48; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; cAMP response element binding protein binding; transcription coactivator activity; chromatin binding; transcription factor activity; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; positive regulation of transforming growth factor-beta2 production; response to osmotic stress; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; regulation of transcription from RNA polymerase II promoter; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription, DNA-dependent; regulation of transcription factor activity; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; response to DNA damage stimulus
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Product References and Citations for anti-ATF-2 antibody

   Maekawa T., EMBO J. 8:2023-2028(1989).
Yang L., J. Immunol. 158:2522-2525(1997).
Hillier L.W., Nature 434:724-731(2005).
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 Research Articles on ATF-2    1. Data show that salvianolic acid B protects endothelial progenitor cells against oxidative stress by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATF-2 antibodyPathways associated with anti-ATF-2 antibody
 Reference Product  PubMed Publications
 JUN antibody  >394 publications with ATF-2 and JUN
 MAPK8 antibody  >22 publications with ATF-2 and MAPK8
 ATM antibody  >9 publications with ATF-2 and ATM
 MAPK14 antibody  >9 publications with ATF-2 and MAPK14
 JDP2 antibody  >6 publications with ATF-2 and JDP2
 RUVBL2 antibody  >1 publications with ATF-2 and RUVBL2
 MAPK11 antibody  >1 publications with ATF-2 and MAPK11
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
Diseases associated with anti-ATF-2 antibodyOrgans/Tissues associated with anti-ATF-2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >71 publications with ATF-2 and Necrosis
 Inflammation Antibodies  >47 publications with ATF-2 and Inflammation
 Nervous System Diseases Antibodies  >33 publications with ATF-2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >32 publications with ATF-2 and Disease Models, Animal
 Brain Diseases Antibodies  >27 publications with ATF-2 and Brain Diseases
 Cardiovascular Diseases Antibodies  >25 publications with ATF-2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >25 publications with ATF-2 and Breast Neoplasms
 Liver Diseases Antibodies  >19 publications with ATF-2 and Liver Diseases
 Neoplasms, Experimental Antibodies  >18 publications with ATF-2 and Neoplasms, Experimental
 Lung Diseases Antibodies  >16 publications with ATF-2 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >83 publications with ATF-2 and Blood
 Brain Antibodies  >79 publications with ATF-2 and Brain
 Muscle Antibodies  >54 publications with ATF-2 and Muscle
 Lung Antibodies  >39 publications with ATF-2 and Lung
 Bone Antibodies  >38 publications with ATF-2 and Bone
 Nerve Antibodies  >37 publications with ATF-2 and Nerve
 Liver Antibodies  >37 publications with ATF-2 and Liver
 Vascular Antibodies  >37 publications with ATF-2 and Vascular
 Kidney Antibodies  >29 publications with ATF-2 and Kidney
 Skin Antibodies  >26 publications with ATF-2 and Skin
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