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anti-ATF-2 antibody :: ATF-2 Antibody

Scan QR to view Datasheet Catalog #    MBS853080
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATF-2, Antibody

 Also Known As   

ATF-2 (Ab-472) Antibody

 Product Synonym Names    Activating 2; ATF2; cAMP response element binding protein CRE-BP1; CREB2; CREBP1; Cyclic-AMP-dependent ATF-2; HB16; MXBP protein
 Product Gene Name   

anti-ATF-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123811
 3D Structure    ModBase 3D Structure for P15336
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    ATF-2 (Ab-472) antibody detects endogenous levels of total ATF-2 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human ATF-2 around the phosphorylation site of serine 472 (A-L-SP-Q-I).
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-ATF-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ATF-2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ATF-2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ATF-2 antibody    WB: 1:500~1:1000
ELISA: 1:20000
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 Western Blot (WB) of anti-ATF-2 antibody    Western blot analysis of extracts from HeLa cells and 293 cells, using ATF-2 (Ab-472) antibody.
anti-ATF-2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ATF-2. It may not necessarily be applicable to this product.
 NCBI GI #    368711269
 NCBI GeneID    1386
 NCBI Accession #    NP_001243019.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256090.1 [Other Products]
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 UniProt Primary Accession #    P15336 [Other Products]
 UniProt Secondary Accession #    Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5 [Other Products]
 UniProt Related Accession #    P15336 [Other Products]
 Molecular Weight    15,409 Da
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 NCBI Official Full Name    cyclic AMP-dependent transcription factor ATF-2 isoform 1
 NCBI Official Synonym Full Names    activating transcription factor 2
 NCBI Official Symbol    ATF2 [Similar Products]
 NCBI Official Synonym Symbols   
HB16; CREB2; TREB7; CREB-2; CRE-BP1
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-2
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-2
 UniProt Synonym Protein Names   
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
 UniProt Gene Name    ATF2 [Similar Products]
 UniProt Synonym Gene Names    CREB2; CREBP1; cAMP-dependent transcription factor ATF-2; CREB-2; cAMP-responsive element-binding protein 2 [Similar Products]
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 NCBI Summary for ATF-2    This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
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 UniProt Comments for ATF-2    Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
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Product References and Citations for anti-ATF-2 antibody

   Maekawa T., EMBO J. 8:2023-2028(1989). Yang L., J. Immunol. 158:2522-2525(1997). Hillier L.W., Nature 434:724-731(2005).
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 Research Articles on ATF-2    1. ATF2 regulated by miR-204 might also play an important role in the regulation of malignant behavior of glioblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATF-2 antibodyPathways associated with anti-ATF-2 antibody
 Reference Product  PubMed Publications
 JUN antibody  >369 publications with ATF-2 and JUN
 FOS antibody  >78 publications with ATF-2 and FOS
 MAPK8 antibody  >20 publications with ATF-2 and MAPK8
 MAPK3 antibody  >20 publications with ATF-2 and MAPK3
 HMGA1 antibody  >10 publications with ATF-2 and HMGA1
 SMAD4 antibody  >8 publications with ATF-2 and SMAD4
 ATF7 antibody  >7 publications with ATF-2 and ATF7
 SMAD3 antibody  >7 publications with ATF-2 and SMAD3
 YY1 antibody  >5 publications with ATF-2 and YY1
 MAPK14 antibody  >5 publications with ATF-2 and MAPK14
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
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 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
Diseases associated with anti-ATF-2 antibodyOrgans/Tissues associated with anti-ATF-2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >143 publications with ATF-2 and Neoplasms
 Necrosis Antibodies  >64 publications with ATF-2 and Necrosis
 Skin Diseases Antibodies  >37 publications with ATF-2 and Skin Diseases
 Inflammation Antibodies  >37 publications with ATF-2 and Inflammation
 Nervous System Diseases Antibodies  >32 publications with ATF-2 and Nervous System Diseases
 Disease Models, Animal Antibodies  >28 publications with ATF-2 and Disease Models, Animal
 Brain Diseases Antibodies  >25 publications with ATF-2 and Brain Diseases
 Breast Neoplasms Antibodies  >25 publications with ATF-2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >24 publications with ATF-2 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >16 publications with ATF-2 and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >75 publications with ATF-2 and Blood
 Brain Antibodies  >71 publications with ATF-2 and Brain
 Muscle Antibodies  >46 publications with ATF-2 and Muscle
 Nerve Antibodies  >35 publications with ATF-2 and Nerve
 Vascular Antibodies  >32 publications with ATF-2 and Vascular
 Lung Antibodies  >32 publications with ATF-2 and Lung
 Bone Antibodies  >30 publications with ATF-2 and Bone
 Kidney Antibodies  >27 publications with ATF-2 and Kidney
 Liver Antibodies  >27 publications with ATF-2 and Liver
 Skin Antibodies  >25 publications with ATF-2 and Skin
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