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anti-ATM antibody :: anti-Human, Mouse ATM Antibody

Scan QR to view Datasheet Catalog #    MBS857400
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATM, Antibody

 Also Known As   

ATM (Phospho-Ser1981) Antibody

 Product Synonym Names    A-T; mutated; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated homolog; Serine-protein kinase ATM; kinase ATM
 Product Gene Name   

anti-ATM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    208900
 3D Structure    ModBase 3D Structure for Q13315
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 Species Reactivity    Human, Mouse
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 Specificity    ATM (phospho-Ser1981) antibody detects endogenous levels of ATM only when phosphorylated at serine 1981.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human ATM around the phosphorylation site of serine 1981 (E-G-SP-Q-S).
 All Sites    Human: Ser1981
Mouse: Ser1987
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-ATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ATM antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-ATM antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-ATM antibody    IHC: 1:50-1:100
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 Immunohistochemistry (IHC) of anti-ATM antibody    P-Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM (phospho-Ser1981) antibody.
anti-ATM antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
 NCBI GI #    71902540
 NCBI GeneID    472
 NCBI Accession #    NP_000042.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000051.3 [Other Products]
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 UniProt Primary Accession #    Q13315 [Other Products]
 UniProt Secondary Accession #    O15429; Q12758; Q16551; Q93007; Q9NP02; Q9UCX7; B2RNX5 [Other Products]
 UniProt Related Accession #    Q13315 [Other Products]
 Molecular Weight    350,687 Da
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 NCBI Official Full Name    serine-protein kinase ATM isoform a
 NCBI Official Synonym Full Names    ATM serine/threonine kinase
 NCBI Official Symbol    ATM [Similar Products]
 NCBI Official Synonym Symbols   
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
[Similar Products]
 NCBI Protein Information    serine-protein kinase ATM
 UniProt Protein Name    Serine-protein kinase ATM
 UniProt Synonym Protein Names   
Ataxia telangiectasia mutated; A-T mutated
 Protein Family    ATM interactor
 UniProt Gene Name    ATM [Similar Products]
 UniProt Synonym Gene Names    A-T mutated [Similar Products]
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 NCBI Summary for ATM    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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 UniProt Comments for ATM    Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
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Product References and Citations for anti-ATM antibody

   Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252. Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.
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 Research Articles on ATM    1. ATM was downregulated in gastric cancer patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATM antibodyPathways associated with anti-ATM antibody
 Reference Product  PubMed Publications
 BRCA1 antibody  >421 publications with ATM and BRCA1
 H2AFX antibody  >292 publications with ATM and H2AFX
 TP53 antibody  >271 publications with ATM and TP53
 MRE11A antibody  >152 publications with ATM and MRE11A
 TP53BP1 antibody  >90 publications with ATM and TP53BP1
 CHEK2 antibody  >73 publications with ATM and CHEK2
 RAD17 antibody  >54 publications with ATM and RAD17
 KAT5 antibody  >21 publications with ATM and KAT5
 CHEK1 antibody  >11 publications with ATM and CHEK1
 ABL1 antibody  >1 publications with ATM and ABL1
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
Diseases associated with anti-ATM antibodyOrgans/Tissues associated with anti-ATM antibody
 Disease Name  Pubmed Publications
 Ataxia Telangiectasia Antibodies  >3292 publications with ATM and Ataxia Telangiectasia
 Neoplasms Antibodies  >1729 publications with ATM and Neoplasms
 Nervous System Diseases Antibodies  >1351 publications with ATM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1181 publications with ATM and Cardiovascular Diseases
 Brain Diseases Antibodies  >1153 publications with ATM and Brain Diseases
 Chromosome Aberrations Antibodies  >397 publications with ATM and Chromosome Aberrations
 Breast Neoplasms Antibodies  >383 publications with ATM and Breast Neoplasms
 Heart Diseases Antibodies  >285 publications with ATM and Heart Diseases
 Disease Models, Animal Antibodies  >260 publications with ATM and Disease Models, Animal
 Drug Toxicity Antibodies  >228 publications with ATM and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1214 publications with ATM and Blood
 Brain Antibodies  >670 publications with ATM and Brain
 Vascular Antibodies  >463 publications with ATM and Vascular
 Lung Antibodies  >415 publications with ATM and Lung
 Heart Antibodies  >276 publications with ATM and Heart
 Muscle Antibodies  >217 publications with ATM and Muscle
 Skin Antibodies  >166 publications with ATM and Skin
 Liver Antibodies  >158 publications with ATM and Liver
 Kidney Antibodies  >153 publications with ATM and Kidney
 Nerve Antibodies  >145 publications with ATM and Nerve
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