NP_001003803.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
24,866 Da
NCBI Official Full Name
ATP synthase subunit s, mitochondrial isoform a
NCBI Official Synonym Full Names
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
NCBI Protein Information
ATP synthase subunit s, mitochondrial; ATP synthase-coupling factor B; ATP synthase coupling factor B-like 1; ATP synthase coupling factor B, mitochondrial; mitochondrial ATP synthase regulatory component factor B; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B)
UniProt Protein Name
ATP synthase subunit s, mitochondrial
UniProt Synonym Protein Names
ATP synthase-coupling factor B; FB; Mitochondrial ATP synthase regulatory component factor B
UniProt Synonym Gene Names
UniProt Entry Name
ATP5S_HUMAN
NCBI Summary for ATP5S
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP5S
ATP5S: Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. Belongs to the ATP synthase subunit s family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 14q21.3
Cellular Component: proton-transporting ATP synthase complex, coupling factor F(o); mitochondrial inner membrane
Molecular Function: metal ion binding; hydrogen ion transmembrane transporter activity
Biological Process: cellular metabolic process; proton transport; mitochondrial ATP synthesis coupled proton transport
Research Articles on ATP5S
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Pathways associated with anti-ATP5S antibody
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