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anti-AXL antibody :: Rabbit AXL (Phospho-Tyr691) Antibody

Scan QR to view Datasheet Catalog #    MBS001060
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AXL (Phospho-Tyr691), Antibody

★Popular Item★
 Also Known As   

Rabbit AXL (Phospho-Tyr691) Antibody

 Product Synonym Names    Adhesion-related kinase; ARK; AXL oncogene; EC 2.7.10.1; kinase AXL; Tyrosine-protein kinase receptor UFO precursor; UFO
 Product Gene Name   

anti-AXL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (41725108..41767671). Location: 19q13.1
 OMIM    109135
 3D Structure    ModBase 3D Structure for P30530
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 Host    Rabbit
 Species Reactivity    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
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 Specificity    AXL (Phospho-Tyr691) antibody detects endogenous levels of AXL only when phosphorylated at tyrosine 691.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human AXL around the phosphorylation site of tyrosine 691(K-I-YP-N-G).
 Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
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 Preparation and Storage    Store at -20C/1 year
 Other Notes    Small volumes of anti-AXL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-AXL antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-AXL antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000
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 Immunohistochemistry of anti-AXL antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using AXL (Phospho-Tyr691) antibody.
anti-AXL antibody Immunohistochemistry (IHC) image
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 Western blot of anti-AXL antibody    Western blot analysis of extracts from HUVEC cells, treated with EGF (200ng/ml, 15mins), using AXL (Phospho-Tyr691) antibody.
anti-AXL antibody Western blot image
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NCBI/Uniprot data below describe general gene information for AXL. It may not necessarily be applicable to this product.
 NCBI GI #    21536468
 NCBI GeneID    558
 NCBI Accession #    NP_001690.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001699.4 [Other Products]
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 UniProt Primary Accession #    P30530 [Other Products]
 UniProt Secondary Accession #    Q8N5L2; Q9UD27 [Other Products]
 UniProt Related Accession #    P30530 [Other Products]
 Molecular Weight    98,336 Da
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 NCBI Official Full Name    tyrosine-protein kinase receptor UFO isoform 2
 NCBI Official Synonym Full Names    AXL receptor tyrosine kinase
 NCBI Official Symbol    AXL [Similar Products]
 NCBI Official Synonym Symbols   
UFO; JTK11
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase receptor UFO; AXL oncogene; oncogene AXL; AXL transforming sequence/gene
 UniProt Protein Name    Tyrosine-protein kinase receptor UFO
 UniProt Synonym Protein Names   
AXL oncogene
 Protein Family    Tyrosine-protein kinase receptor
 UniProt Gene Name    AXL [Similar Products]
 UniProt Synonym Gene Names    UFO [Similar Products]
 UniProt Entry Name    UFO_HUMAN
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 NCBI Summary for AXL    The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AXL    AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Oncoprotein; Protein kinase, TK; TK group; Axl family

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; phosphatidylserine binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding; myosin heavy chain binding

Biological Process: forebrain cell migration; negative regulation of lymphocyte activation; platelet activation; organ regeneration; peptidyl-tyrosine phosphorylation; cell maturation; neuron migration; vagina development; negative regulation of tumor necrosis factor production; signal transduction; phagocytosis; positive regulation of natural killer cell differentiation; erythrocyte homeostasis; positive regulation of protein kinase B signaling cascade; ovulation cycle; natural killer cell differentiation; negative regulation of interferon-gamma production; protein kinase B signaling cascade; cellular response to extracellular stimulus; innate immune response; blood vessel remodeling; spermatogenesis; negative regulation of neuron apoptosis; positive regulation of cytokine and chemokine mediated signaling pathway; inflammatory response; vascular endothelial growth factor receptor signaling pathway; apoptotic cell clearance; secretion by cell
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 Research Articles on AXL    1. The Axl receptor shedding is an active process affected and influenced by the Gas6-mediated Axl-signaling in systemic lupus erythematosus and Behcets disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AXL antibodyDiseases associated with anti-AXL antibody
 Reference Product  PubMed Publications
 GAS6 antibody  >212 publications with AXL and GAS6
 SRC antibody  >20 publications with AXL and SRC
 GRB2 antibody  >8 publications with AXL and GRB2
 ADAM10 antibody  >3 publications with AXL and ADAM10
 TENC1 antibody  >3 publications with AXL and TENC1
 SOCS1 antibody  >3 publications with AXL and SOCS1
 PTPN11 antibody  >2 publications with AXL and PTPN11
 SHC1 antibody  >2 publications with AXL and SHC1
 LCK antibody  >1 publications with AXL and LCK
 CBL antibody  >1 publications with AXL and CBL
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >155 publications with AXL and Neoplasms
 Carcinoma Antibodies  >62 publications with AXL and Carcinoma
 Inflammation Antibodies  >47 publications with AXL and Inflammation
 Neoplasm Metastasis Antibodies  >31 publications with AXL and Neoplasm Metastasis
 Nervous System Diseases Antibodies  >29 publications with AXL and Nervous System Diseases
 Adenocarcinoma Antibodies  >28 publications with AXL and Adenocarcinoma
 Disease Models, Animal Antibodies  >28 publications with AXL and Disease Models, Animal
 Lung Neoplasms Antibodies  >26 publications with AXL and Lung Neoplasms
 Breast Neoplasms Antibodies  >25 publications with AXL and Breast Neoplasms
 Necrosis Antibodies  >25 publications with AXL and Necrosis
Organs/Tissues associated with anti-AXL antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >76 publications with AXL and Vascular
 Brain Antibodies  >45 publications with AXL and Brain
 Eye Antibodies  >43 publications with AXL and Eye
 Muscle Antibodies  >40 publications with AXL and Muscle
 Lung Antibodies  >39 publications with AXL and Lung
 Kidney Antibodies  >38 publications with AXL and Kidney
 Bone Antibodies  >34 publications with AXL and Bone
 Bone Marrow Antibodies  >27 publications with AXL and Bone Marrow
 Liver Antibodies  >24 publications with AXL and Liver
 Embryonic Tissue Antibodies  >16 publications with AXL and Embryonic Tissue
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