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anti-HIST2H4A antibody :: Rabbit Acetyl-Histone H4 Antibody

Scan QR to view Datasheet Catalog #    MBS8508967 anti-HIST2H4A antibody
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acetyl-Histone H4 (HIST2H4A), Antibody

 Also Known As   

Acetyl-Histone H4 (Lys5) Antibody

 Product Synonym Names    H4F2; HIST; HIST1H4A; Histone H4.AC-H4K5;H4K5
 Product Gene Name   

anti-HIST2H4A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615069
 3D Structure    ModBase 3D Structure for P62805
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Other Notes    Small volumes of anti-HIST2H4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HIST2H4A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

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NCBI/Uniprot data below describe general gene information for HIST2H4A. It may not necessarily be applicable to this product.
 NCBI GI #    51317339
 NCBI GeneID    8370
 NCBI Accession #    P62805.2 [Other Products]
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 UniProt Primary Accession #    P62805 [Other Products]
 UniProt Secondary Accession #    P02304; P02305; Q6DRA9; Q6FGB8; Q6NWP7; A2VCL0 [Other Products]
 UniProt Related Accession #    P62805 [Other Products]
 Molecular Weight    11,367 Da [Similar Products]
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 NCBI Official Full Name    Histone H4
 NCBI Official Synonym Full Names    histone cluster 2, H4a
 NCBI Official Symbol    HIST2H4A [Similar Products]
 NCBI Official Synonym Symbols   
H4; H4/n; H4F2; H4FN; FO108; HIST2H4
[Similar Products]
 NCBI Protein Information    histone H4; histone 2, H4a; H4 histone, family 2; histone IV, family 2; H4 histone family, member N
 UniProt Protein Name    Histone H4
 UniProt Gene Name    HIST1H4A [Similar Products]
 UniProt Synonym Gene Names    H4/A; H4FA [Similar Products]
 UniProt Entry Name    H4_HUMAN
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 NCBI Summary for HIST2H4A    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HIST2H4A    H4: histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H4 is intronless.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleus

Molecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activity

Biological Process: chromatin silencing at rDNA; establishment and/or maintenance of chromatin architecture; regulation of gene expression, epigenetic; DNA replication-dependent nucleosome assembly; negative regulation of megakaryocyte differentiation; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; DNA replication-independent nucleosome assembly; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; mitotic cell cycle; telomere maintenance; DNA methylation on cytosine
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 Research Articles on HIST2H4A    1. NASP balances the activity of the heat shock proteins Hsc70 and Hsp90 to direct H3-H4 for degradation by chaperone-mediated autophagy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIST2H4A antibody
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
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