NP_000672.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-2A adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2A
NCBI Official Synonym Symbols
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR [Similar Products]
NCBI Protein Information
alpha-2A adrenergic receptor
UniProt Protein Name
Alpha-2A adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
UniProt Synonym Gene Names
NCBI Summary for ADA2A
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for ADA2A
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
Product References and Citations for anti-ADA2A antibody
Kobilka B.K., Science 238:650-656(1987). Fraser C.M., J. Biol. Chem. 264:11754-11761(1989). Guyer C.A., J. Biol. Chem. 265:17307-17317(1990).
Research Articles on ADA2A
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Products associated with anti-ADA2A antibody
Pathways associated with anti-ADA2A antibody
Diseases associated with anti-ADA2A antibody
Organs/Tissues associated with anti-ADA2A antibody
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